Evidence map›Paper›PMID 39907992›Full record

ArticleJournal of vascular research2025

Evaluation of Metabolism-Associated Proteins in Abdominal Aortic Aneurysm.

Amanda Balboa Ramilo, Nikiforos Chandrinos, Elefantia Tsichlia, Josefin Jönsson, Kevin Mani, Anders Wanhainen, Dick Wågsäter

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Article in Journal of vascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amanda Balboa RamiloDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Nikiforos ChandrinosDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Elefantia TsichliaDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Josefin JönssonDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Kevin ManiDepartment of Surgical Sciences, Vascular Surgery, Uppsala University, Uppsala, Sweden.
Anders WanhainenDepartment of Surgical Sciences, Vascular Surgery, Uppsala University, Uppsala, Sweden.
Dick WågsäterDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAbdominal aortic aneurysm (AAA) development is inversely associated with diabetes mellitus. Targeting glucose metabolism seems to be a beneficial strategy for preventing AAA growth. Several metabolism-related factors are associated with AAA development. This study aimed to analyse the expression of the so far unstudied proteins irisin, follistatin, activin A, and ghrelin (ligand and receptor) in human and murine aneurysmal tissue, to assess the involvement of these pathways in AAA.

methodsGene and protein expression was evaluated in aneurysmal and control tissue samples, by qPCR and immunohistochemistry. Vascular smooth muscle cells (VSMCs) were studied in vitro for expression. Circulating levels of the proteins of interest in human plasma samples were evaluated by ELISA.

resultsIn human aneurysmal tissue, the proteins of interest were predominantly expressed by VSMCs in neovessels. Expression by human VSMCs was confirmed in vitro. In human plasma, the concentration of irisin was higher in AAA (+/- diabetes) compared to controls. Patients with AAA and type 2 diabetes treated with metformin had lower levels of follistatin and ghrelin.

conclusionThis study demonstrates irisin, follistatin, and ghrelin as interesting proteins to be studied in the context of the observed negative association between AAA development and type 2 diabetes.

Indexed as

Aorta, AbdominalAortic Aneurysm, AbdominalDiabetes Mellitus, Type 2FibronectinsFollistatinGhrelinMuscle, Smooth, VascularMyocytes, Smooth MuscleActivinsAgedAnimalsCase-Control StudiesCells, CulturedFemaleHumansHypoglycemic Agentsactivin AActivinsFibronectinsFNDC5 protein, humanFollistatinFST protein, humanGhrelinGHRL protein, humanHypoglycemic AgentsMetforminAbdominal aortic aneurysmActivin AFollistatinGhrelinIrisin

Identifiers

PMID39907992
PMCPMC12136604

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.