Evidence map›Paper›PMID 39907911›Full record

ArticleInfection2025

Echovirus serotype 11 induced sepsis in a young female patient with multiple sclerosis treated with anti-CD20 monoclonal antibody ocrelizumab.

A D Starosta, J Ehler, B Löffler, A Tannapfel, A Zipprich, P A Reuken, A Stallmach

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Enterovirus infections in children.Pediatric investigation · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

A D StarostaDepartment of Internal Medicine III (Nephrology, Rheumatology, Endocrinology), Jena University Hospital - Friedrich Schiller University, Jena, Germany.
J EhlerDepartment of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.
B LöfflerInstitute of Medical Microbiology, Jena University Hospital - Friedrich Schiller University, Jena, Germany.
A TannapfelInstitute of Pathology, Ruhr University Bochum, Bochum, Germany.
A ZipprichDepartment of Internal Medicine IV (Gastroenterology, Hepatology and Infectious Diseases), Jena University Hospital - Friedrich Schiller University, Am Klinikum 1, 07743, Jena, Germany.ORCID http://orcid.org/0000-0001-8403-7983
P A ReukenDepartment of Internal Medicine IV (Gastroenterology, Hepatology and Infectious Diseases), Jena University Hospital - Friedrich Schiller University, Am Klinikum 1, 07743, Jena, Germany.ORCID http://orcid.org/0000-0002-7696-475X
A StallmachDepartment of Internal Medicine IV (Gastroenterology, Hepatology and Infectious Diseases), Jena University Hospital - Friedrich Schiller University, Am Klinikum 1, 07743, Jena, Germany. andreas.stallmach@med.uni-jena.de.ORCID http://orcid.org/0000-0002-6101-5244

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEnterovirus infection has been described as a cause of severe viral sepsis in humorally immunosuppressed patients. CASE PRESENTATION: A 20-year-old female with a history of multiple sclerosis on ocrelizumab therapy with persistent agammaglobulinemia and autoimmune hepatitis treated with azathioprine/budesonide presented with subacute sensorineural hearing loss, hepatitis, pneumonia, enterocolitis and pancreatitis. Molecular pathological techniques detected enterovirus RNA in samples from the liver, blood, ascites fluid, and pleural effusions, confirming Echovirus serotype 11. The case was managed successfully with supportive care and high-dose intravenous immunoglobulins in addition to fluoxetine. DISCUSSION AND

conclusionsThis patient's unique presentation and clinical course presents important implications for the care of immunosuppressed patients with cryptic complaints.

Indexed as

Antibodies, Monoclonal, HumanizedEchovirus InfectionsEnterovirus B, HumanMultiple SclerosisSepsisFemaleHumansImmunocompromised HostImmunosuppressive AgentsSerogroupYoung AdultAntibodies, Monoclonal, HumanizedImmunosuppressive AgentsocrelizumabAnti-CD20-therapyEchovirusEnterovirusHepatitisImmunosuppresionMultiple sclerosis

Identifiers

PMID39907911
PMCPMC12316724

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.