Evidence map›Paper›PMID 39907885›Full record

SynthesisClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2025

Efficacy and safety of S-ketamine in pain management for breast cancer patients undergoing modified radical mastectomy: a meta-analysis of randomized controlled trials.

Bilal Abu-Hussein, Amr Elrosasy, Haidy Samy, Ahmed Said Ali, Said Samir Alijla, Ahmad Naoras Bitar, Ibrahim Gamal

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bilal Abu-HusseinOrthopedic Department University Hospital Southampton, Southampton, England.ORCID http://orcid.org/0000-0003-0426-6298
Amr ElrosasyFaculty of Medicine, Cairo University, Cairo, Egypt. 10912022103193@stud.cu.edu.eg.ORCID http://orcid.org/0000-0002-5592-3908
Haidy SamyFaculty of Physical Therapy, Modern University for Technology and Information, Cairo, Egypt.
Ahmed Said AliFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Said Samir AlijlaDepartment of Anesthesiology, Algerian Hospital, Palestine Military Medical Services, Bethlehem, Palestine.
Ahmad Naoras BitarDepartment of Clinical Pharmacy, Faculty of Pharmacy, Universiti Sultan Zainal Abidin, Jalan Tembila, 22200, Besut, Terengganu, Malaysia.
Ibrahim GamalFaculty of Medicine, Al-Azhar University, Cairo, Egypt.ORCID http://orcid.org/0000-0001-9579-1244

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreast cancer remains a leading cause of morbidity and mortality among women worldwide. According to the recent statistics by World Health Organization (WHO), it is the leading cause of death from cancer in women worldwide and it is the most frequently diagnosed cancer. This meta-analysis aims to systematically evaluate the efficacy and safety of S-ketamine in patients undergoing modified radical mastectomy.

methodWe searched five databases; PubMed, Scopus, Science Direct, Web of Science, and Medline Plus. We included six studies. The applicable outcomes for meta-analysis about efficacy and safety of S-ketamine in patients undergoing modified radical mastectomy.

resultsSix RCTs included in our meta-analysis found that Esketamine group had a statistically significant lower VAS score after 4 h, after 6 h, after 24 h, after 48 h; (MD = -1.54; 95% CI [-1.65, -1.42], P < 0.00001), (MD = -0.55; 95% CI [-0.66, -0.45], P < 0.00001), (MD = -0.75; 95% CI [-0.84, -0.66], P < 0.00001,), (MD = -0.26; 95% CI [-0.48, -0.03], P = 0.03) P < 0.00001), respectively.

conclusionWe conclude that S-ketamine is valuable for reducing pain and safe in patients undergoing modified radical mastectomy.

Indexed as

AnalgesicsBreast NeoplasmsKetamineMastectomy, Modified RadicalPain ManagementPostoperative PainFemaleHumansRandomized Controlled Trials as TopicAnalgesicsEsketamineKetamineBreast cancerRadical mastectomyS-ketamineVAS

Identifiers

PMID39907885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.