Evidence map›Paper›PMID 39907866›Full record

ArticleNatural products and bioprospecting2025

Design, synthesis and biological evaluation of buthutin derivatives as cardioprotective agents.

Yuan Liu, Fa-Qi Wang, Xin-Hao Hua, Shu-Han Yang, Li-Ning Wang, Yun-Sheng Xu, Chen-Yue Shao, Xiang-Bo Gou, Yu-Ming Liu

Abstract read
In one paragraph

Article in Natural products and bioprospecting, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuan LiuDepartment of Pharmacy Engineering, Tianjin University of Technology, Tianjin, 300384, People's Republic of China.
Fa-Qi WangDepartment of Pharmacy Engineering, Tianjin University of Technology, Tianjin, 300384, People's Republic of China.
Xin-Hao HuaDepartment of Pharmacy Engineering, Tianjin University of Technology, Tianjin, 300384, People's Republic of China.
Shu-Han YangDepartment of Pharmacy Engineering, Tianjin University of Technology, Tianjin, 300384, People's Republic of China.
Li-Ning WangCollege of Traditional Chinese Medicine, Tianjin Univerisity of Traditional Chinese Medicine, Tianjin, 300193, People's Republic of China.
Yun-Sheng XuDepartment of Pharmacy Engineering, Tianjin University of Technology, Tianjin, 300384, People's Republic of China.
Chen-Yue ShaoDepartment of Pharmacy Engineering, Tianjin University of Technology, Tianjin, 300384, People's Republic of China.
Xiang-Bo GouDepartment of Pharmacy Engineering, Tianjin University of Technology, Tianjin, 300384, People's Republic of China. gouxiangbo@163.com.
Yu-Ming LiuDepartment of Pharmacy Engineering, Tianjin University of Technology, Tianjin, 300384, People's Republic of China. coumarin1968@hotmail.com.ORCID http://orcid.org/0000-0003-4235-3915

Funding

National Natural Science Foundation of China 82204397
6 · The paper itself

Abstract

Natural products are the important sources in cardiovascular drug development. In this study, twenty-nine buthutin derivatives were designed, synthesized, and evaluated for their NHE-1 inhibition and protective effects on cardiomyocyte injury. The structure of the newly synthesized compounds had been confirmed by

Indexed as

Amide-guanidine derivativesButhus martensiiCardioprotective agentsNHE-1

Identifiers

PMID39907866
PMCPMC11799461

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.