Evidence map›Paper›PMID 39907861›Full record

ReviewHead and neck pathology2025

Sclerosing Odontogenic Carcinoma: A Unique Odontogenic Carcinoma with Metastatic Potential.

Tayla Malherbe, Anneze Odendaal, Jos Hille, Leon Janse van Rensburg, Mark Meyer, Etienne Myburgh, Amir H Afrogheh

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Head and neck pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tayla MalherbeDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of the Western Cape, Cape Town, South Africa.
Anneze OdendaalDepartment of Oral Medicine and Periodontology, Faculty of Dentistry, University of the Western Cape, Cape Town, South Africa.
Jos HilleDepartment of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tygerberg Hospital, University of the Western Cape, Cape Town, South Africa.
Leon Janse van RensburgDepartment of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Mark MeyerDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of the Western Cape, Cape Town, South Africa.
Etienne MyburghPanorama Centre for Surgical Oncology, 60 Hennie Winterbach St, Panorama, Cape Town, South Africa.
Amir H AfroghehDepartment of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tygerberg Hospital, University of the Western Cape, Cape Town, South Africa. amir.afrogheh@nhls.ac.za.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe recent World Health Organization (WHO) classification of odontogenic tumours defines Sclerosing Odontogenic Carcinoma (SOC) as a rare primary intraosseous carcinoma (PIOC) of the jaws. With the exception of one case, there have been no cases of SOC with metastatic disease. We report a unique case of SOC with neck node metastases, further expanding the clinical, radiological and histological spectrum of this rare intriguing tumour.

methodsA 52-year-old female presented with a destructive radiolucent lesion of right mandible. Incisional biopsy was interpreted as desmoplastic ameloblastoma. The segmental mandibulectomy specimen was histologically consistent with SOC with positive anterior margin. Further resection with neck dissection revealed positive right levels IB and IIA nodes. Immunohistochemistry and Fluroscent In Situ Hybridization (FISH) were performed to confirm the diagnosis.

resultsThe tumour was positive for CK5, p63, p40 and negative for CK19, CK20, CK7, SOX-10, S100, ER, PR, BRAFV600E, and EWSR1 gene rearrangements. Ki67 was 15%.

conclusionTo avoid confusion with PIOC, a high grade squamous cell carcinoma of the jaws with poor prognosis, SOC may be best defined as a rare infiltrative and locally aggressive odontogenic carcinoma with metastatic potential but with a reasonably favourable outcome. SOC shares similar histologic features with many benign and malignant tumours. An appropriate panel of immunohistochemical markers, in conjunction with special stains and molecular studies can help refine the differential diagnosis. It appears that a Ki67 proliferation index of more than 10%, may pose a risk for nodal metastasis and may assist in planning the clinical management. To achieve lower rates of positive margins and tumour recurrence, a wider resection margin (more than a centimetre) is recommended.

Indexed as

Mandibular NeoplasmsOdontogenic TumorsBiomarkers, TumorFemaleHumansLymphatic MetastasisMiddle AgedBiomarkers, TumorCCOCDesmoplastic ameloblastomaEWSR1ImmunohistochemistryKi67 proliferation indexMetastasisPrimary intraosseous carcinomaRecurrenceSclerosing odontogenic carcinomaWHO classification

Identifiers

PMID39907861
PMCPMC11799462

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