Evidence map›Paper›PMID 39907839›Full record

ReviewCurrent nutrition reports2025

Nutritional and Therapeutic Potential of Longan Fruit By-products for Liver Diseases: Pathway to Functional Foods.

Idris Kaida Zubairu, Kanyasiri Rakariyatham, Shitapan Bai-Ngew, Noppol Leksawasdi, Joe M Regenstein, Fei Lao, Hui Hong, Weon-Sun Shin, Khalid J Alzahrani, Yuthana Phimolsiripol

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current nutrition reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Idris Kaida ZubairuFaculty of Agro-Industry, Chiang Mai University, Chiang Mai, 50100, Thailand.
Kanyasiri RakariyathamFaculty of Agro-Industry, Chiang Mai University, Chiang Mai, 50100, Thailand.
Shitapan Bai-NgewFaculty of Agro-Industry, Chiang Mai University, Chiang Mai, 50100, Thailand.
Noppol LeksawasdiFaculty of Agro-Industry, Chiang Mai University, Chiang Mai, 50100, Thailand.
Joe M RegensteinDepartment of Food Science, Cornell University, Ithaca, NY, 14853-7201, USA.
Fei LaoCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Hui HongCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Weon-Sun ShinCollege of Human Ecology, Hanyang University, Seoul, Republic of Korea.
Khalid J AlzahraniDepartment of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
Yuthana PhimolsiripolFaculty of Agro-Industry, Chiang Mai University, Chiang Mai, 50100, Thailand. yuthana.p@cmu.ac.th.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThe massive processing of longan fruit consequently generates a significant quantity of by-products that are a nuisance to the environment. This review aims to tap these by-products for sustainable applications in treating hepatic diseases. RECENT

findingsEthnobotanical investigations show that longan fruit has been utilized in liver functioning for over two millennia and is supported by contemporary scientific findings. Recent studies highlighted that these by-products contain bioactive compounds that decrease oxidative stress and inflammation, key drivers of liver diseases, including liver fibrosis, hepatitis, and non-alcoholic fatty liver disease (NAFLD). These bioactive compounds modulate lipid metabolism, detoxification pathways, and oxidative stress-regulating metabolic pathways of hepatoprotection. In addition, using longan by-products provides a relatively more affordable nutraceutical substitute for synthetic pharmaceuticals. This literature revealed that polyphenolic compounds such as corilagin gallic acid, ellagic acid, and various flavonoids in longan by-products exhibit antioxidant, anti-inflammatory, and immunomodulatory activities that benefit liver health through different pathways including unexplored mechanisms. However, this review recommends exploring the potential functional application of these by-products in food. It emphasizes the need for clinical validation of longan by-product therapies for liver diseases.

Indexed as

FruitFunctional FoodLiver DiseasesAnimalsAnti-Inflammatory AgentsAntioxidantsDietary SupplementsHumansNon-alcoholic Fatty Liver DiseaseOxidative StressAnti-Inflammatory AgentsAntioxidantsBioactive compoundsFunctional foodHepatic diseaseHepatic therapyHepatoprotection mechanismsLongan fruit by-products

Identifiers

PMID39907839

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.