Evidence map›Paper›PMID 39907821›Full record

ArticleEuropean journal of pediatrics2025

Specific airway resistance according to early maternal vitamin D status during pregnancy in children aged 5 to 6 years old from the FEPED cohort (RESPIFEPED).

Apolline Gonsard, Fabienne Marquant, Caroline Elie, Muriel Le Bourgeois, Véronique Houdouin, Christophe Delclaux, Nicole Beydon, Adèle Bellino, Jean-Claude Souberbielle, Isabelle Sermet-Gaudelus and 3 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03229317 (Respiratory Outcome According to Early Maternal Vitamin D Status During Pregnancy in Children Aged 5 to 6 Years Old), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03229317 completednot on this map

Respiratory Outcome According to Early Maternal Vitamin D Status During Pregnancy in Children Aged 5 to 6 Years Old

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2018 to 2020Enrolled142ConditionsAsthma in ChildrenArmsPlethysmography
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Apolline GonsardDepartment of Pediatric Pulmonology and Allergology, University Hospital Necker-Enfants Malades, AP-HP, Paris, France. apollinegonsard@yahoo.fr.
Fabienne MarquantURC/CIC Paris Centre Université Paris Cité, Hôpital Necker-Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France.
Caroline ElieURC/CIC Paris Centre Université Paris Cité, Hôpital Necker-Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France.
Muriel Le BourgeoisDepartment of Pediatric Pulmonology and Allergology, University Hospital Necker-Enfants Malades, AP-HP, Paris, France.
Véronique HoudouinPediatric Pulmonology and Allergology Department, Robert Debré University Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
Christophe DelclauxPediatric Functional Unit and Sleep Center, Robert Debré University Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
Nicole BeydonAP-HP. Sorbonne - Université, Unité Fonctionnelle de Physiologie - Explorations Fonctionnelles Respiratoires et du Sommeil, Hôpital Armand Trousseau, INSERM, U 938, Centre de Recherche Saint Antoine, Hôpital Saint-Antoine, Paris, France.
Adèle BellinoURC/CIC Paris Centre Université Paris Cité, Hôpital Necker-Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France.
Jean-Claude SouberbiellePhysiology Department, Necker-Enfants Malades University Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
Isabelle Sermet-GaudelusDepartment of Pediatric Pulmonology and Allergology, University Hospital Necker-Enfants Malades, AP-HP, Paris, France.
Christophe DelacourtDepartment of Pediatric Pulmonology and Allergology, University Hospital Necker-Enfants Malades, AP-HP, Paris, France.
Alexandra BenachiDepartment of Obstetrics and Gynecology, Antoine Béclère University Hospital, AP-HP, Clamart, France.
Alice HadchouelDepartment of Pediatric Pulmonology and Allergology, University Hospital Necker-Enfants Malades, AP-HP, Paris, France.

Funding

Programme Hospitalier de Recherche Clinique Interrégional AOR16009
6 · The paper itself

Abstract

There are conflicting results on the association between maternal vitamin D concentrations during pregnancy and respiratory outcomes for their offspring. However, published studies have mainly focused on the second and third trimesters of pregnancy or on high-risk population. The main objective of this study was to evaluate the association between vitamin D plasma concentrations in the first trimester (T1) of pregnancy and effective specific airway resistance (sR

conclusionIn a cohort of young children, airway resistance and asthma were not associated with early vitamin D deficiency during pregnancy.

trial registrationThis study is registered with the ClinicalTrials.gov identifier NCT03229317. WHAT IS KNOWN: • There are conflicting results on the association between maternal vitamin D concentrations during pregnancy and respiratory outcomes for their offspring. However, published studies have mainly focused on the second and third trimesters of pregnancy or on high-risk population. WHAT IS NEW: • In a cohort of 5- to 6-year-old children assessed prospectively, there was no significant difference in sReff or any other lung function measurements depending on maternal vitamin D status during the first trimester of pregnancy.

Indexed as

Airway ResistanceAsthmaPrenatal Exposure Delayed EffectsVitamin DVitamin D DeficiencyAdultBronchiolitisChildChild, PreschoolCohort StudiesFemaleFetal BloodHumansMalePregnancyPregnancy Trimester, FirstVitamin D25(OH)DAirway resistanceAsthmaChildhood asthmaPregnancyPulmonary function testVitamin D

Identifiers

PMID39907821
PMCPMC11799076

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Registered trials

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