Evidence map›Paper›PMID 39907790›Full record

ArticleEuropean child & adolescent psychiatry2025

Association between aggression and ADHD polygenic scores and school-age aggression: the mediating role of preschool externalizing behaviors and adverse experiences.

Mélanie Bouliane, Michel Boivin, Tina Kretschmer, Bianca Lafreniere, Stéphane Paquin, Richard Tremblay, Sylvana Côté, Jean-Philippe Gouin, Till F M Andlauer, Amélie Petitclerc and 1 more

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Article in European child & adolescent psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mélanie BoulianeSchool of Criminology, University of Montreal, Montreal, Canada.
Michel BoivinSchool of Psychology, Laval University, Quebec City, Canada.
Tina KretschmerUniversity of Groningen, Groningen, Netherlands.
Bianca LafreniereResearch Center of the Montreal Mental Health University Institute, Montreal, Canada.
Stéphane PaquinDepartment of Psychology, Pennsylvania State University, University Park, PA, USA.
Richard TremblaySainte-Justine Hospital Research Center, Montreal, Canada.
Sylvana CôtéSainte-Justine Hospital Research Center, Montreal, Canada.
Jean-Philippe GouinDepartment of Psychology, Concordia University, Montreal, Canada.
Till F M AndlauerDepartment of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
Amélie PetitclercSchool of Psychology, Laval University, Quebec City, Canada.
Isabelle Ouellet-MorinSchool of Criminology, University of Montreal, Montreal, Canada. isabelle.ouellet-morin@umontreal.ca.

Funding

Horizon 2020 Research and Innovation program 757364
6 · The paper itself

Abstract

Individual differences in physical aggression (PA) are largely heritable. However, it remains unclear how genetic propensity for aggression manifests early in life and relates to school-age PA. Preschool externalizing behavior problems (EXT) and adverse experiences are known predictors of school-age PA and also partly heritable. We investigated whether early childhood EXT and adverse experiences mediated the association between polygenic scores and school-age PA. Genotype data collected from 721 participants in the Quebec Longitudinal Study of Child Development (45% males) were used to derive polygenic scores for aggression (PGS

Indexed as

Adverse Childhood ExperiencesAggressionAttention Deficit Disorder with HyperactivityChild BehaviorMultifactorial InheritanceAdolescentChildChild, PreschoolFemaleHumansLongitudinal StudiesMaleQuebecAdverse experiencesAggressionAttention deficit/hyperactivity disorderExternalizing behavior problemsLongitudinal studyPolygenic score

Identifiers

PMID39907790

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.