ArticleSocial psychiatry and psychiatric epidemiology2025
Gender differences in the association between childhood trauma, clinical symptoms, and cognitive function in Chinese patients with chronic schizophrenia.
Article in Social psychiatry and psychiatric epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Differential associations of childhood trauma subtypes with clinical symptoms, cognitive function, suicidal intent, and age at onset in Chinese patients with chronic schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Interrelationships of childhood trauma, psychiatric symptoms, neurocognition, and insomnia in chronic schizophrenia: a network perspective.European archives of psychiatry and clinical neuroscience · 2026Article
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5 authors.
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Abstract
purposeThis study investigates the gender-specific associations between childhood trauma, clinical symptoms, and cognitive function in Chinese patients with chronic schizophrenia.
methodsA total of 601 patients with chronic schizophrenia were evaluated using the Childhood Trauma Questionnaire-Short Form (CTQ-SF), the Positive and Negative Syndrome Scale (PANSS), and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Correlation and regression analyses were performed to explore the relationships between childhood trauma and clinical symptoms and cognitive function, considering gender differences.
resultsChildhood trauma prevalence showed no gender differences. In male patients, physical neglect predicted PANSS Positive symptoms (β = 0.123), and physical abuse was linked to lower Visuospatial Construction scores (β = -0.103). In female patients, emotional neglect predicted PANSS Positive (β = 0.225) and Excitement factors (β = 0.197), and emotional abuse predicted Depressive symptoms (β = 0.186). Sexual abuse was associated with lower language scores (β = -0.204), and physical neglect with deficits in Immediate (β = -0.261) and Delayed Memory (β = -0.157).
conclusionThe findings highlight distinct gender-specific patterns in the impact of childhood trauma on clinical symptoms among patients with chronic schizophrenia. This suggests the necessity for gender-specific therapeutic interventions to address these differences effectively.
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