Evidence map›Paper›PMID 39907723›Full record

ArticleThe Journal of experimental medicine2025

No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis.

Antje Blumenthal, Leslie C Domínguez Cadena

Abstract read
In one paragraph

Article in The Journal of experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Antje BlumenthalFrazer Institute, The University of Queensland , Brisbane, Australia.ORCID 0000-0003-3673-7015
Leslie C Domínguez CadenaFrazer Institute, The University of Queensland , Brisbane, Australia.ORCID 0000-0002-6212-8785

Funding

Australian Research Council Future Fellowship FT220100487National Health and Medical Research Council of Australia GNT2027755
6 · The paper itself

Abstract

Bernaleau et al. (https://doi.org/10.1084/jem.20240825) show that CCDC134 located in the ER is required for TLR biogenesis by controlling the N-glycosylation, folding, and stabilization of the ER chaperone Gp96.

Indexed as

Endoplasmic ReticulumMembrane GlycoproteinsMolecular ChaperonesSugarsToll-Like ReceptorsAnimalsGlycosylationHumansProtein FoldingendoplasminMembrane GlycoproteinsMolecular ChaperonesSugarsToll-Like Receptors

Identifiers

PMID39907723
PMCPMC11797005

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.