ArticleAbdominal radiology (New York)2025
Layering hyperintensity in T1-weighted magnetic resonance imaging predicts gallbladder sludge: a retrospective cohort and diagnostic accuracy study in patients with significant liver disease.
Article in Abdominal radiology (New York), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Free-breathing Three-dimensional MR Cholangiopancreatography Using Centric k-space Encoding Improved Gallbladder Visualization: A Prospective Study.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026Article
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Abstract
backgroundLayering hyperintensity in the gallbladder is frequently observed on T1-weighted (T1w) magnetic resonance imaging (MRI), but its association with hepatobiliary disorders is not well understood.
objectiveThis study aimed to evaluate the prevalence of T1w layering in the gallbladder and its correlation with ultrasound (US) findings and patient characteristics in a cohort with significant liver disease.
methodsA single-center study from 2015 to 2022 included patients who underwent MRI and abdominal US within one week. Exclusion criteria were poor imaging quality and prior cholecystectomy. MRI findings were correlated with US and analyzed against patient characteristics.
resultsAmong 415 patients (mean age 58.3 ± 14.8 years; mean BMI 28.0 ± 4.5 kg/m²), 67% had abnormal liver function tests, with high prevalences of cirrhosis (n = 260), transjugular intrahepatic portosystemic shunt (TIPS) (n = 233), and choledocholithiasis (n = 106). T1w layering was observed in 56% (n = 232) and associated with higher BMI (p = 0.001) and with cholecystolithiasis (p < 0.001), but not with age, sex, or liver disease indicators. T1w layering was predictive of gallbladder sludge on US (odds ratio 17.2, 95% confidence interval 9.87-31.44, p < 0.001), with a sensitivity of 92.7% but moderate specificity (57.9%).
conclusionT1w layering on MRI strongly predicts gallbladder sludge detected on US and is associated with increased BMI in this cohort of patients with liver disease. However, the moderate specificity requires cautious interpretation, and our findings suggest that T1w layering may serve as a complementary diagnostic tool.
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