Evidence map›Paper›PMID 39907709›Full record

ArticleJournal of molecular histology2025

E2F1-Dependent CDCA5 overexpression drives cervical cancer progression and correlates with poor prognosis.

Youhui Wang, Wuguang Zhang, Min Peng

Abstract read
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Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Youhui WangTumor Radiotherapy and Chemotherapy Center, Ningbo University Affiliated People's Hospital, No. 251, Baizhang East Road, Ningbo, 315040, Zhejiang, China. wangyouhui0012@163.com.
Wuguang ZhangTumor Radiotherapy and Chemotherapy Center, Ningbo University Affiliated People's Hospital, No. 251, Baizhang East Road, Ningbo, 315040, Zhejiang, China.
Min PengTumor Radiotherapy and Chemotherapy Center, Ningbo University Affiliated People's Hospital, No. 251, Baizhang East Road, Ningbo, 315040, Zhejiang, China.

Funding

Zhejiang Province Traditional Chinese Medicine Science and Technology Plan 2018ZB123
6 · The paper itself

Abstract

Cervical cancer (CC) remains a leading cause of cancer-related mortality in women worldwide, highlighting the urgent need for novel therapeutic strategies. This study investigates the molecular mechanisms and clinical significance of Cell Division Cycle Associated 5 (CDCA5) in cervical cancer progression. We performed comprehensive analyses of CDCA5 expression in cervical cancer and normal tissues, correlating expression levels with clinicopathological features and patient outcomes. Functional studies using CC cell lines (SiHa, HeLa, and CaSki) examined the effects of CDCA5 manipulation on tumor cell behavior. We identified E2F1 as a key transcriptional regulator of CDCA5 and validated our findings using in vivo xenograft models. CDCA5 was significantly upregulated in CC tissues and correlated with advanced disease stages and poor survival outcomes. Mechanistically, CDCA5 depletion in SiHa and HeLa cells suppressed proliferation, migration, and invasion, while its overexpression in CaSki cells enhanced these malignant properties. We identified E2F1 as a transcriptional activator of CDCA5. Importantly, CDCA5 knockdown significantly inhibited tumor growth in nude mouse models. Our findings establish CDCA5 as a critical E2F1-regulated oncogenic factor in cervical cancer progression. The strong correlation between CDCA5 expression and poor clinical outcomes suggests its potential as both a prognostic biomarker and therapeutic target in cervical cancer treatment.

Indexed as

Adaptor Proteins, Signal TransducingCell Cycle ProteinsE2F1 Transcription FactorGene Expression Regulation, NeoplasticUterine Cervical NeoplasmsAnimalsCell Line, TumorCell MovementCell ProliferationDisease ProgressionFemaleHeLa CellsHumansMiceMice, NudePrognosisAdaptor Proteins, Signal TransducingCDCA5 protein, humanCell Cycle ProteinsE2F1 protein, humanE2F1 Transcription FactorCDCA5Cell proliferationCervical cancerE2F1InvasionMigrationTherapeutic target

Identifiers

PMID39907709

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.