Evidence map›Paper›PMID 39907688›Full record

ReviewThe journal of applied laboratory medicine2025

High-Sensitivity Cardiac Troponin Assays: From Implementation to Resource Utilization and Cost Effectiveness.

Hong-Kee Lee, Cian P McCarthy, Allan S Jaffe, Richard Body, Ahmed Alotaibi, Yader Sandoval, James L Januzzi

Abstract readReview
In one paragraph

Review in The journal of applied laboratory medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Biomarkers in Heart Failure: A Review and a Wish.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hong-Kee LeeDepartment of Pathology and Laboratory Medicine, Endeavor Health, Evanston, IL, United States.
Cian P McCarthyDivision of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Allan S JaffeDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, United States.ORCID 0000-0003-1183-3959
Richard BodyDepartment of Emergency Medicine, University of Manchester, Manchester, United Kingdom.ORCID 0000-0001-9089-8130
Ahmed AlotaibiDepartment of Emergency Medicine, University of Manchester, Manchester, United Kingdom.
Yader SandovalMinneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, MN, United States.ORCID 0000-0003-4800-2972
James L JanuzziDivision of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.ORCID 0000-0002-8338-1798

Funding

Improving the Health Status of Individuals with Type 2 Myocardial InfarctionK23HL167659 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Cian Patrick McCarthy · 2023 to 2026
$786k
NHLBI NIH HHS K23 HL167659
6 · The paper itself

Abstract

backgroundCardiac troponin is the gold-standard biomarker for the evaluation of patients with suspected acute myocardial infarction (MI). Improvements in assay technology have led to high-sensitivity cardiac troponin assays that, when incorporated into accelerated diagnostic pathways, may rapidly diagnose or exclude acute MI more efficiently than conventional troponin assays. CONTENT: In this narrative review, we provide practical suggestions for implementing high-sensitivity cardiac troponin assays, review accelerated diagnostic pathways incorporating these assays, and review the impact of these assays on resource utilization and cost-effectiveness in relation to the evaluation of individuals with possible acute MI. SUMMARY: An increasing number of hospitals are transitioning to high-sensitivity cardiac troponin assays. This narrative review provides an overview of the potential benefits of this transition.

Indexed as

Myocardial InfarctionTroponinBiomarkersCost-Benefit AnalysisCost-Effectiveness AnalysisHumansSensitivity and SpecificityBiomarkersTroponin

Identifiers

PMID39907688
PMCPMC12068378

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.