Evidence map›Paper›PMID 39907586›Full record

ArticleRadiology. Artificial intelligence2025

Performance of Lung Cancer Prediction Models for Screening-detected, Incidental, and Biopsied Pulmonary Nodules.

Thomas Z Li, Kaiwen Xu, Aravind Krishnan, Riqiang Gao, Michael N Kammer, Sanja Antic, David Xiao, Michael Knight, Yency Martinez, Rafael Paez and 7 more

Abstract read
In one paragraph

Article in Radiology. Artificial intelligence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Thomas Z LiMedical Scientist Training Program, Vanderbilt University, Nashville, Tenn.ORCID 0000-0001-9950-4679
Kaiwen XuDepartment of Computer Science, Vanderbilt University, Nashville, Tenn.ORCID 0000-0002-2664-255X
Aravind KrishnanDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, Tenn.ORCID 0009-0000-1829-8245
Riqiang GaoDepartment of Digital Technology and Innovation, Siemens Healthineers, Princeton, NJ.ORCID 0000-0002-8729-1941
Michael N KammerDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.
Sanja AnticDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.
David XiaoDepartment of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tenn.ORCID 0000-0002-1423-8146
Michael KnightDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.ORCID 0009-0001-3490-9576
Yency MartinezDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.
Rafael PaezDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.
Robert J LentzDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.
Stephen DeppenDepartment of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tenn.ORCID 0000-0002-3661-662X
Eric L GroganDepartment of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tenn.
Thomas A LaskoDepartment of Computer Science, Vanderbilt University, Nashville, Tenn.ORCID 0000-0003-2300-9529
Kim L SandlerDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tenn.ORCID 0000-0003-2989-248X
Fabien MaldonadoDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.ORCID 0000-0002-6504-2063
Bennett A LandmanDepartment of Biomedical Engineering, Vanderbilt University, 2301 Vanderbilt Pl, Nashville, TN 37235.ORCID 0000-0001-5733-2127

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Validation of Biomarkers of Risk for the Early Detection of Lung CancerU01CA152662 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DEPPEN, STEPHEN, GROGAN, ERIC L · 2010 to 2025
$12.8M
Novel Integrative Approach for the Early Detection of Lung Cancer using Repeated MeasuresR01CA253923 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LANDMAN, BENNETT A., MALDONADO, FABIEN · 2021 to 2025
$3.4M
Training Program for Innovative Engineering Research in Surgery and InterventionT32EB021937 · NIBIB · VANDERBILT UNIVERSITY · PI Dario J Englot, Michael Ian Miga · 2016 to 2026
$2.3M
Risk stratifying indeterminate pulmonary nodules with jointly learned features from longitudinal radiologic and clinical big dataF30CA275020 · NCI · VANDERBILT UNIVERSITY · PI LI, THOMAS ZHIHE · 2023 to 2025
$141k
NCATS NIH HHS UL1 TR002243NCI NIH HHS F30 CA275020NCI NIH HHS R01 CA253923NCI NIH HHS U01 CA152662NIBIB NIH HHS T32 EB021937
6 · The paper itself

Abstract

Purpose To evaluate the performance of eight lung cancer prediction models on patient cohorts with screening-detected, incidentally detected, and bronchoscopically biopsied pulmonary nodules. Materials and Methods This study retrospectively evaluated promising predictive models for lung cancer prediction in three clinical settings: lung cancer screening with low-dose CT, incidentally detected pulmonary nodules, and nodules deemed suspicious enough to warrant a biopsy. The area under the receiver operating characteristic curve of eight validated models, including logistic regressions on clinical variables and radiologist nodule characterizations, artificial intelligence (AI) on chest CT scans, longitudinal imaging AI, and multimodal approaches for prediction of lung cancer risk was assessed in nine cohorts (

Indexed as

Artificial IntelligenceEarly Detection of CancerLung NeoplasmsMultiple Pulmonary NodulesSolitary Pulmonary NoduleTomography, X-Ray ComputedAgedBiopsyFemaleHumansIncidental FindingsLungMaleMiddle AgedPredictive Value of TestsRetrospective StudiesApplication DomainClassificationDiagnosisLung

Identifiers

PMID39907586
PMCPMC11950892

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.