Evidence map›Paper›PMID 39907554›Full record

ArticleeLife2025

A model-based factorization method for scRNA data unveils bifurcating transcriptional modules underlying cell fate determination.

Jun Ren, Ying Zhou, Yudi Hu, Jing Yang, Hongkun Fang, Xuejing Lyu, Jintao Guo, Xiaodong Shi, Qiyuan Li

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jun RenNational Institute for Data Science in Health and Medicine, School of Medicine, Xiamen University, Xiamen, China.ORCID https://orcid.org/0000-0002-9027-2303
Ying ZhouNational Institute for Data Science in Health and Medicine, School of Medicine, Xiamen University, Xiamen, China.
Yudi HuNational Institute for Data Science in Health and Medicine, School of Medicine, Xiamen University, Xiamen, China.
Jing YangNational Institute for Data Science in Health and Medicine, School of Medicine, Xiamen University, Xiamen, China.
Hongkun FangDepartment of Scientific Research Management, Weifang People's Hospital, Shandong Second Medical University, Weifang, China.
Xuejing LyuNational Institute for Data Science in Health and Medicine, School of Medicine, Xiamen University, Xiamen, China.
Jintao GuoDepartment of Scientific Research Management, Weifang People's Hospital, Shandong Second Medical University, Weifang, China.
Xiaodong ShiSchool of Informatics, Xiamen University, Xiamen, Xiamen, China.
Qiyuan LiNational Institute for Data Science in Health and Medicine, School of Medicine, Xiamen University, Xiamen, China.ORCID https://orcid.org/0000-0002-8934-8948

Funding

National Key Research and Development Program of China 2022YFC2704801National Natural Science Foundation of China 82203420National Natural Science Foundation of China 82272944
6 · The paper itself

Abstract

Manifold-learning is particularly useful to resolve the complex cellular state space from single-cell RNA sequences. While current manifold-learning methods provide insights into cell fate by inferring graph-based trajectory at cell level, challenges remain to retrieve interpretable biology underlying the diverse cellular states. Here, we described MGPfact

Indexed as

Computational BiologyRNA, Small CytoplasmicSingle-Cell AnalysisAnimalsCD8-Positive T-LymphocytesCell DifferentiationHumansMiceRNA, Small Cytoplasmicbifurcation processcomputational biologyfactorizationhumanmanifold-learningmixtures of Gaussian processesmousescRNA-seqsystems biology

Identifiers

PMID39907554
PMCPMC11798574

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.