Evidence map›Paper›PMID 39907500›Full record

ArticleAging2025

Carriers of Parkinson's disease-linked SNCA Rep1 variant have greater non-motor decline: a 4 year follow up study.

Aarthi Santhanakrishnan, Yi Jayne Tan, Seyed Ehsan Saffari, Yi Zhao, Ebonne Y L Ng, Samuel Y E Ng, Nicole S Y Chia, Xinyi Choi, Dede Heng, Shermyn Neo and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Aarthi SanthanakrishnanLee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Yi Jayne TanDepartment of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.
Seyed Ehsan SaffariDepartment of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.
Yi ZhaoDepartment of Clinical Translational Research, Singapore General Hospital, Singapore.
Ebonne Y L NgDepartment of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore.
Samuel Y E NgDepartment of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.
Nicole S Y ChiaDepartment of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.
Xinyi ChoiDepartment of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore.
Dede HengDepartment of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore.
Shermyn NeoDepartment of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.
Zheyu XuDepartment of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.
Kay Yaw TayDepartment of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.
Wing Lok AuDepartment of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.
Eng-King TanDepartment of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore.
Louis C S TanDepartment of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.
Adeline S L NgDepartment of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alpha-synuclein gene promoter (SNCA Rep1) polymorphism has been linked to Parkinson's Disease (PD) susceptibility and motor symptom severity, but less is known about its longitudinal relationship with non-motor symptom severity. To address this gap, this is the first longitudinal study over 4 years investigating the relationship between Rep1 allele length and non-motor function amongst 208 early PD patients grouped into long (

Indexed as

alpha-SynucleinParkinson DiseaseAgedAllelesFemaleFollow-Up StudiesGenetic Predisposition to DiseaseHeterozygoteHumansLongitudinal StudiesMaleMiddle AgedPromoter Regions, Geneticalpha-SynucleinSNCA protein, humanapathycognitiongeneticsmemoryParkinson’s disease

Identifiers

PMID39907500
PMCPMC11892927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.