Evidence map›Paper›PMID 39907455›Full record

ArticleApplied and environmental microbiology2025

Antimicrobial peptide DiPGLa-H exhibits the most outstanding anti-infective activity among the PGLa variants based on a systematic comparison.

Liangjun Zheng, Muhammad Zafir, Ziqian Zhang, Yadong Ma, Fengyi Yang, Xiaokun Wang, Xuemei Xue, Chen Wang, Ping Li, Pilong Liu and 3 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Liangjun Zheng *Department of Animal Science and Technology, University of Northwest A&F, Yangling, Shaanxi, China.
Muhammad Zafir *Department of Animal Science and Technology, University of Northwest A&F, Yangling, Shaanxi, China.
Ziqian ZhangDepartment of Animal Science and Technology, University of Northwest A&F, Yangling, Shaanxi, China.
Yadong MaDepartment of Animal Science and Technology, University of Northwest A&F, Yangling, Shaanxi, China.
Fengyi YangDepartment of Animal Science and Technology, University of Northwest A&F, Yangling, Shaanxi, China.
Xiaokun WangDepartment of Animal Science and Technology, University of Northwest A&F, Yangling, Shaanxi, China.
Xuemei XueDepartment of Animal Science and Technology, University of Northwest A&F, Yangling, Shaanxi, China.
Chen WangDepartment of Animal Science and Technology, University of Northwest A&F, Yangling, Shaanxi, China.
Ping LiOlymbel Bioengineering Institute, Zhangye, Gansu, China.
Pilong LiuDepartment of Animal Science and Technology, University of Northwest A&F, Yangling, Shaanxi, China.ORCID 0000-0003-1981-5341
Fatma A El-GoharyDepartment of Hygiene and Zoonoses, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
Xin ZhaoDepartment of Animal Science, McGill University, Sainte-Anne-de-Bellevue, Québec, Canada.ORCID 0000-0002-1078-7332
Huping XueDepartment of Animal Science and Technology, University of Northwest A&F, Yangling, Shaanxi, China.ORCID 0000-0002-7808-7164

Funding

MOST | National Natural Science Foundation of China (NSFC) 31972652Shaanxi Fundamental Science Research Project for Chemistry & Biology 22JHQ055Shanghai Frontiers Science Center of Drug Target Identification and Delivery ZXWH2170101Sichuan Agricultural University (SAU) Animal Disease-resistant Nutrition SZ2024-01-01Xi'an city Science program 24NYGG0021
6 · The paper itself

Abstract

The escalating threat of antibiotic-resistant bacteria has heightened global interest in antimicrobial peptides as promising candidates due to their potent broad-spectrum activity and low likelihood of resistance development. Despite this potential, these peptides face challenges, including modest bactericidal efficacy, insufficient safety assessment, and expensive production. In this study, we systematically evaluated a panel of nine AMP variants of PGLa, a natural AMP derived from IMPORTANCE: AMPs are innate defense molecules in animals, plants, and microorganisms. Notably, one-third of these peptides in databases originate from amphibians. We discovered that naturally weak AMPs from this source can be enhanced through artificial design. Specifically, variant DiPGLa-H showed superior germicidal efficacy and cell selectivity both

Indexed as

Anti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesAcinetobacter baumanniiAnimalsEscherichia coliMiceMicrobial Sensitivity TestsStaphylococcus aureusXenopus laevisAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesAMPsbiosynthesisDAMP4DiPGLa-Hnon-chromatographic purification

Identifiers

PMID39907455
PMCPMC11921344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.