ArticleJournal of experimental botany2025
Impact of m6A modification and transcript quantity on mRNA composition in plant stress granules under hypoxia.
Article in Journal of experimental botany, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Trehalose's untapped mechanisms in alzheimer's: gut-brain-autophagy signalling beyond the usual targets.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026Review
- Pathogen-triggered m⁶A epitranscriptomic reprogramming is linked to host defense responses in the Piper nigrum-Phytophthora capsici pathosystem.Plant cell reports · 2026Article
- Comprehensive Genomic Characterization of mInternational journal of molecular sciences · 2026Article
- Bioimaging insights into structural pathways of cell-to-cell communication within the male (MGU) and female (FGU) germ units of Arabidopsis thaliana.Plant cell reports · 2025Article
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10 authors.
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Abstract
Stress granules (SGs) are cytoplasmic structures that appear in response to unfavorable environmental conditions. The mechanisms governing the accumulation of transcripts in SGs are only partially understood, and despite the recognized role of N6-methyladenosine (m6A) in plant transcriptome regulation, its impact on SG composition and assembly remains unknown. In Lupinus angustifolius, SGs display a distinctive bi-zonal structure comprising of a ring and a central area with differences in their ultrastructure and composition. Following a transcriptome analysis, specific mRNAs were chosen to investigate their localization within SGs and to assess m6A levels. Transcripts of hypoxia-responsive genes (ADH1 and HUP7) showed significantly lower levels of m6A compared to housekeeping genes, but only ADH1 was absent in SGs. HUP7 mRNA, characterized by a low quantity of m6A, was present both in the SGs and the cytoplasm, probably due to an extremely high expression level. The m6A modification was observed only during the assembly of SGs. In mutants of Arabidopsis with reduced levels of m6A, ECT2 (a reader of m6A) was not observed in SGs, and poly(A) RNA levels and the number of SGs were reduced. Our findings thus demonstrate a limited impact of m6A modification on SG assembly; however, the interplay between m6A modification and the overall transcript quantity in the cytoplasm appears to play a regulatory role in mRNA partitioning and assembly of SGs.
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