Evidence map›Paper›PMID 39907305›Full record

ArticleJournal of the American Geriatrics Society2025

Associations of Accelerometer-Measured Physical Activity With Dementia, Anxiety, and Depression Among Older Adults.

Eric L Stulberg, Lin-Na Chou, Shweta Gore, Molly B Conroy, Jennifer J Majersik, Katherine J Hunzinger, Alexander LaPoint, Mandeep Kaur Sandhu, Andrea L C Schneider, Amit Kumar

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eric L StulbergDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-3075-4597
Lin-Na ChouDepartment of Physical Therapy & Athletic Training, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0003-0779-714X
Shweta GoreDepartment of Physical Therapy, Massachusetts General Hospital Institute of Health Professions, Boston, Massachusetts, USA.
Molly B ConroyDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
Jennifer J MajersikDepartment of Neurology, University of Utah, Salt Lake City, Utah, USA.
Katherine J HunzingerDepartment of Exercise Science, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-4599-8543
Alexander LaPointUniversity of Utah School of Medicine, Salt Lake City, Utah, USA.
Mandeep Kaur SandhuDepartment of Physical Therapy, University of Texas Medical Branch, Galveston, Texas, USA.
Andrea L C SchneiderDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Amit KumarDepartment of Physical Therapy & Athletic Training, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0002-0125-6759

Funding

Establishing Mechanisms Between Traumatic Brain Injury and Dementia Using Epidemiology, Clinical Studies, Blood-Based Biomarkers, and Neuroimaging BiomarkersK23NS123340 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Andrea Lauren Christman Schneider · 2022 to 2026
$1.1M
Utah Stimulating Access to Research in ResidencyR38HL167282 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Margaret B Conroy, JOSEPH BARNEY STANFORD · 2023 to 2026
$924k
Functional Biomarkers for Prediction of Hospitalization, Long-Term Care Placement, and Mortality in Older Adults with Cardiometabolic MultimorbidityR15AG070730 · NIA · MGH INSTITUTE OF HEALTH PROFESSIONS · PI GORE, SHWETA, KUMAR, AMIT · 2022 to 2022
$501k
NHLBI NIH HHS 1R38HL167282-01NHLBI NIH HHS R38 HL167282NIA NIH HHS 1R15AG070730-01A1NIA NIH HHS R15 AG070730NINDS NIH HHS K23 NS123340NINDS NIH HHS K23NS123340
6 · The paper itself

Abstract

backgroundHigher physical activity (PA) is associated with better neuropsychiatric health, but prior studies have been limited by cross-sectional designs, self-reported PA measures, and small numbers of older individuals. We examined associations between baseline and changes in accelerometer-measured moderate-vigorous PA (MVPA) with neuropsychiatric health among individuals aged ≥ 70 years in the National Health and Aging Trends Study.

methodsWe used the average daily minutes of accelerometer-measured MVPA above a validated threshold of 2184 counts per minute as a continuous measure at baseline for the exposure variable. For longitudinal analyses, we categorized change in MVPA as follows: an increase of > 20 min/day over 1 year, a decrease of > 20 min/day over 1 year, and staying within 20 min/day over 1 year. Our outcomes were possible/probable dementia and anxiety or depression. Associations were estimated using confounder-adjusted logistic regressions.

resultsIn our survey-weighted analytic sample of 639 individuals aged ≥ 70 years, 56% were ≥ 75 years, and 53% were female. After adjusting for confounders, a 20-min/day higher baseline MVPA was significantly associated with lower odds of possible/probable dementia 1 year later (odds ratio [OR] = 0.89, 95% confidence interval [CI] = 0.83-0.96) but not with depression and anxiety symptoms. Compared to no change in PA over 1 year, an increase in MVPA by > 20 min/day was associated with decreased odds of depression and anxiety symptoms (OR = 0.06, 95% CI = 0.03-0.14) but not with possible/probable dementia. Compared to no change in MVPA over 1 year, a decrease in MVPA by > 20 min/day was associated with higher odds of possible/probable dementia (OR = 3.82, 95% CI = 1.34-10.87) but not with depression and anxiety symptoms.

conclusionsHigher and increasing MVPA over time is associated with better neuropsychiatric health in individuals aged ≥ 70 years. Future studies should prioritize evaluating detailed PA trajectories to better understand how different doses, intensities, and modalities of PA impact neuropsychiatric decline in older adults.

Indexed as

AccelerometryAnxietyDementiaDepressionExerciseAgedAged, 80 and overCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleUnited Statesanxietydementiadepressiongeriatricsphysical activity

Identifiers

PMID39907305
PMCPMC12205289

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.