Evidence map›Paper›PMID 39907284›Full record

ArticleJournal of virology2025

Effect of host telomerase inhibition on human cytomegalovirus.

Chloe M Cavanaugh, Cora N Betsinger, Nicole Katchur, Sherry Zhang, Karen Yang, Maciej Nogalski, Ileana M Cristea, Daniel Notterman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Cancers · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chloe M CavanaughDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.ORCID 0000-0002-2560-210X
Cora N Betsinger *Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Nicole Katchur *Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Sherry ZhangDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Karen YangDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Maciej NogalskiDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Ileana M CristeaDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.ORCID 0000-0002-6533-2458
Daniel NottermanDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.ORCID 0000-0002-8809-8297

Funding

Reciprocal Genetic-Environmental Interactions During Childhood and AdolescenceR01HD076592 · NICHD · PRINCETON UNIVERSITY · PI NOTTERMAN, DANIEL A. · 2013 to 2023
$6.8M
Mechanisms mediating immune response upon sensing of nuclear viral DNAR01GM114141 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 2015 to 2023
$2.6M
Dynamic virus-driven remodeling of ER-mitochondria contactsR01AI174515 · NIAID · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 2022 to 2025
$2.2M
NRSA TrainingTL1TR003019 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI SCOTTO, KATHLEEN W. · 2019 to 2023
$1.9M
Mechanism and Therapeutic Implication of Host Cell Telomerase Modulation by Human CytomegalovirusF30AI157182 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI CAVANAUGH, CHLOE M · 2022 to 2025
$213k
Defining the regulation of mitochondrial bioenergetics during virus infectionF31AI154796 · NIAID · PRINCETON UNIVERSITY · PI BETSINGER, CORA NICOLE · 2021 to 2022
$93k
NCATS NIH HHS TL1 TR003019NIAID NIH HHS F30 AI157182NIAID NIH HHS F31 AI154796NIAID NIH HHS R01 AI174515NICHD NIH HHS R01 HD076592NIGMS NIH HHS R01 GM114141
6 · The paper itself

Abstract

Treatment options remain limited for human cytomegalovirus (HCMV). Host telomerase has been implicated in the pathogenesis and oncogenesis of multiple herpesviruses, most recently including HCMV. In this study, we investigated the effect of telomerase inhibition on HCMV replication, as well as the mechanism of the interaction between HCMV and host telomerase IMPORTANCE: Human cytomegalovirus (HCMV) seroprevalence and morbidity in immunocompromised patients and neonates infected

Indexed as

CytomegalovirusCytomegalovirus InfectionsHost-Pathogen InteractionsTelomeraseCell LineFibroblastsHumansVirus ReplicationTelomeraseTERT protein, humancytomegalovirushuman herpesvirusestelomerase

Identifiers

PMID39907284
PMCPMC11915825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.