Evidence map›Paper›PMID 39907280›Full record

ArticleJournal of virology2025

Usutu virus-induced meningoencephalitis in immunocompetent mice is characterized by the recruitment of mononuclear cells and a proinflammatory T helper 1 response.

Rebeca Froes Rocha, Laís D Coimbra, Marina A Fontoura, Guilherme Ribeiro, Giuliana Eboli Sotorilli, Giovanni F Gomes, Alexandre Borin, Jaqueline Felipe, Emily Slowikowski, Wilias Silva Santos Greison and 4 more

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rebeca Froes Rocha *Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo, Brazil.
Laís D Coimbra *Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo, Brazil.ORCID 0000-0003-0120-6898
Marina A FontouraBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo, Brazil.
Guilherme RibeiroGraduate Program in Genetics and Molecular Biology, State University of Campinas, Campinas, São Paulo, Brazil.
Giuliana Eboli SotorilliBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo, Brazil.
Giovanni F GomesCenter for Research in Inflammatory Diseases (CRID), Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, São Paulo, Brazil.
Alexandre BorinBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo, Brazil.
Jaqueline FelipeBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo, Brazil.
Emily SlowikowskiDepartment of Microbiology, Immunology, and Transplantation, Laboratory of Molecular Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Flanders, Belgium.
Wilias Silva Santos GreisonGraduate Program in Genetics and Molecular Biology, State University of Campinas, Campinas, São Paulo, Brazil.
Thiago M CunhaCenter for Research in Inflammatory Diseases (CRID), Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, São Paulo, Brazil.
Pedro Elias MarquesDepartment of Microbiology, Immunology, and Transplantation, Laboratory of Molecular Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Flanders, Belgium.
Pedro M M VieiraGraduate Program in Genetics and Molecular Biology, State University of Campinas, Campinas, São Paulo, Brazil.
Rafael Elias MarquesBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo, Brazil.ORCID 0000-0002-6949-0947

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 141253/2019-3Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) 88887.351846/2019-00Financiadora de Estudos e Projetos (FINEP) 01.20.0003.00Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2021/05519-0, 2018/10990-1, 2016/00194-8, 2019/06459-1, 2020/04558-0, 2018/02594-9, 2019/20772-4Ministério da Ciência, Tecnologia e Inovação (MCTI)
6 · The paper itself

Abstract

Usutu virus (USUV) is an arbovirus and has emerged as a potential cause of encephalitis in humans and other vertebrates. The increasing detection of USUV in mosquitoes and birds across Africa and Central Europe, along with the lack of specific treatments or vaccines for many encephalitic orthoflaviviruses, underscores the need for focused research. In this study, we developed a USUV infection model in immunocompetent C57BL/6 mice (8-12 weeks old) to characterize disease development and associated inflammatory mechanisms. Mice were intracranially infected with 10

Indexed as

FlavivirusFlavivirus InfectionsMeningoencephalitisTh1 CellsAnimalsBrainCytokinesDisease Models, AnimalFemaleMacrophagesMiceMice, Inbred C57BLViral LoadCytokinesflavivirusimmunopathogenesisleukocyte recruitmentmouse modelTh1 responseUsutu virusviral encephalitis

Identifiers

PMID39907280
PMCPMC11915786

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.