Evidence map›Paper›PMID 39907119›Full record

ArticleAIDS research and human retroviruses2025

Lessons Learned in Eliciting Systematic Participant Perspectives in a Combination HIV Cure Research Trial.

Karine Dubé, Hursch Patel, Steven Meanley, Lynda Dee, Anastasia Korolkova, Fang Wan, Shadi Eskaf, Meghann Williams, Rebecca Hoh, Steven G Deeks and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and human retroviruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Karine DubéDivision of Infectious Diseases and Global Public Health (IDGPH), Department of Medicine, University of California San Diego (UCSD), La Jolla, California, USA.ORCID 0000-0003-3458-1539
Hursch PatelDivision of Infectious Diseases and Global Public Health (IDGPH), Department of Medicine, University of California San Diego (UCSD), La Jolla, California, USA.ORCID 0000-0002-0725-4922
Steven MeanleyDepartment of Family and Community Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Lynda DeeAIDS Action Baltimore, Baltimore, Maryland, USA.
Anastasia KorolkovaDivision of Infectious Diseases and Global Public Health (IDGPH), Department of Medicine, University of California San Diego (UCSD), La Jolla, California, USA.
Fang WanDivision of Infectious Diseases and Global Public Health (IDGPH), Department of Medicine, University of California San Diego (UCSD), La Jolla, California, USA.
Shadi EskafPublic Health Research Consultant, Chapel Hill, North Carolina, USA.
Meghann WilliamsDivision of HIV, Infectious Diseases and Global Medicine, Department of Medicine, University of California, San Francsico, San Francisco, California, USA.
Rebecca HohDivision of HIV, Infectious Diseases and Global Medicine, Department of Medicine, University of California, San Francsico, San Francisco, California, USA.
Steven G DeeksDivision of HIV, Infectious Diseases and Global Medicine, Department of Medicine, University of California, San Francsico, San Francisco, California, USA.
Michael J PelusoDivision of HIV, Infectious Diseases and Global Medicine, Department of Medicine, University of California, San Francsico, San Francisco, California, USA.
Jeremy SugarmanJohns Hopkins Berman Institute for Bioethics, Baltimore, Maryland, USA.
John A SaucedaDivision of Prevention Science, Center for AIDS Prevention Studies (CAPS), San Francisco, California, USA.

Funding

Penn Mental Health AIDS Research CenterP30MH097488 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Karine Dube, Kelly L Jordan-Sciutto · 2013 to 2026
$23.5M
Investigating Psychosocial Experiences of HIV Cure Trial Participants Undergoing Extended HIV Treatment Interruptions: Implications for Ethical ConductR01MH126768 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUBE, KARINE, SAUCEDA, JOHN ANDREW · 2021 to 2025
$3.6M
NIMH NIH HHS P30 MH097488NIMH NIH HHS R01 MH126768
6 · The paper itself

Abstract

Current trials toward an HIV cure involve combination strategies aimed at achieving durable antiretroviral treatment (ART)-free viral control or HIV elimination, many relying on analytical treatment interruptions (ATIs) to evaluate efficacy. Given the physical, psychosocial, and interpersonal risks associated with ATIs, it is critical to monitor participants' experiences so that support can be provided when needed. While qualitative approaches have been used in similar settings, we designed and implemented a series of short, closed-ended participant surveys in the University of California, San Francisco-amfAR trial, a single-arm multi-intervention HIV cure-related trial with an extended ATI. Surveys were administered at relevant trial timepoints to capture participants' (

Indexed as

Anti-HIV AgentsHIV InfectionsAdultClinical Trials as TopicFemaleHumansMaleMiddle AgedMotivationSan FranciscoSurveys and QuestionnairesAnti-HIV Agentsanalytical treatment interruptionscombination trialsHIV cure researchparticipant experiencespeople with HIVsociobehavioral research

Identifiers

PMID39907119
PMCPMC12263157

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.