Evidence map›Paper›PMID 39907094›Full record

ArticleCancer reports (Hoboken, N.J.)2025

Adjuvant Proton Beam Radiation Therapy for Sinonasal Mucosal Melanoma.

Jamie S K Takayesu, Upendra Parvathaneni, George E Laramore, Neil Panjwani, Jennifer Sillings, Neal D Futran, Ian M Humphreys, Aria Jafari, Waleed M Abuzeid, Brittany Barber and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer reports (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Surgical margin assessment and prognostic impact in sinonasal cancers: a systematic review and meta-analysis.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025
    Pooled it
  2. Article
  3. Sinonasal Mucosal Melanoma: A Comprehensive Review and Clinical Experience.Journal of rhinology : official journal of the Korean Rhinologic Society · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jamie S K TakayesuDepartment of Radiation Oncology, University of Washington, Seattle, Washington, USA.ORCID 0000-0001-8265-3328
Upendra ParvathaneniDepartment of Radiation Oncology, University of Washington, Seattle, Washington, USA.
George E LaramoreDepartment of Radiation Oncology, University of Washington, Seattle, Washington, USA.
Neil PanjwaniDepartment of Radiation Oncology, University of Washington, Seattle, Washington, USA.
Jennifer SillingsDepartment of Radiation Oncology, University of Washington, Seattle, Washington, USA.
Neal D FutranDepartment of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
Ian M HumphreysDepartment of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
Aria JafariDepartment of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
Waleed M AbuzeidDepartment of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
Brittany BarberDepartment of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
Emily MarchianoDepartment of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington, USA.
Sylvia M LeeDepartment of Hematology and Oncology, University of Washington, Seattle, Washington, USA.
John A ThompsonDepartment of Hematology and Oncology, University of Washington, Seattle, Washington, USA.
Evan HallDepartment of Hematology and Oncology, University of Washington, Seattle, Washington, USA.
Shailender BhatiaDepartment of Hematology and Oncology, University of Washington, Seattle, Washington, USA.
Cristina P RodriguezDepartment of Hematology and Oncology, University of Washington, Seattle, Washington, USA.
Jay J LiaoDepartment of Radiation Oncology, University of Washington, Seattle, Washington, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHead and neck mucosal melanoma (HNMM) is rare and carries a poor prognosis with high rates of disease progression. There is little data regarding the use of adjuvant proton radiation therapy in the management of sinonasal HNMM.

aimsWe performed a retrospective review of patients with nonmetastatic sinonasal HNMM treated with adjuvant proton radiation from 2012 to 2022 at a single academic institution. Kaplan-Meier estimates were used for survival analyses. METHODS AND

resultsEight patients with sinonasal HNMM were treated with surgery and adjuvant proton radiation, and six received systemic therapy. Median follow-up was 15 months (range: 3-68 months). Only one local failure was observed, and two patients developed distant metastases. Kaplan-Meier 1-year results were as follows: local control 88%, distant metastasis-free survival 75%, and overall survival 88%. No Grade 3 or higher late toxicities were observed.

conclusionSurgical resection and adjuvant proton radiation provided early favorable local control and toxicity profiles in our cohort of patients with sinonasal HNMM. Further multi-institutional work is needed to study this rare malignancy.

Indexed as

MelanomaNasal MucosaParanasal Sinus NeoplasmsProton TherapyAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedRadiotherapy, AdjuvantRetrospective Studiesimmunotherapymucosal melanomaprotonsradiation therapysinonasal cancer

Identifiers

PMID39907094
PMCPMC11795273

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.