Evidence map›Paper›PMID 39907091›Full record

ArticleCell transplantation

Evaluating Predictors of Quality in Liver NK Cells Among Deceased Donors.

Yuki Imaoka, Masahiro Ohira, Toshihiro Nakayama, Miho Akabane, Tetsuya Tajima, Shinichiro Yokota, Sheri M Krams, Olivia M Martinez, Carlos O Esquivel, Kazunari Sasaki and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuki ImaokaDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.ORCID 0000-0003-0882-5341
Masahiro OhiraDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Toshihiro NakayamaDivision of Abdominal Transplant, Department of Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
Miho AkabaneDivision of Abdominal Transplant, Department of Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
Tetsuya TajimaDivision of Abdominal Transplant, Department of Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
Shinichiro YokotaDivision of Abdominal Transplant, Department of Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
Sheri M KramsDivision of Abdominal Transplant, Department of Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
Olivia M MartinezDivision of Abdominal Transplant, Department of Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
Carlos O EsquivelDivision of Abdominal Transplant, Department of Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
Kazunari SasakiDivision of Abdominal Transplant, Department of Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
Hideki OhdanDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the substantial variability in the quality of liver natural killer (NK) cells from deceased donors (DDs). This study assessed liver nonparenchymal cells from 51 DDs for activation receptors and cytotoxicity against K562 (leukemia) and HepG2 (hepatoma) cell lines. The results indicated variability in TNF-related apoptosis-inducing ligand (TRAIL) and NK stimulatory receptor NK group 2 member D (NKG2D) expression in liver NK cells from DDs, which correlated with cytotoxicity against tumor cell lines. In addition, the white blood cell (WBC) count, aspartate aminotransferase (AST) level, body mass index (BMI), and platelet count were significantly associated with enhanced TRAIL and NKG2D expression. A predictive score integrating AST/platelet ratio index, BMI, and WBC count was developed to effectively identify DDs with high antitumor activity in liver NK cells. This score is expected to predict DDs with high-quality liver NK cells, which can be used for the purpose of immunotherapies.

Indexed as

Killer Cells, NaturalLiverTissue DonorsTNF-Related Apoptosis-Inducing LigandAdultAgedAspartate AminotransferasesBody Mass IndexFemaleHep G2 CellsHumansK562 CellsLeukocyte CountMaleMiddle AgedNK Cell Lectin-Like Receptor Subfamily KAspartate AminotransferasesKLRK1 protein, humanNK Cell Lectin-Like Receptor Subfamily KTNF-Related Apoptosis-Inducing Ligandantitumor activityhepatocellular carcinomaimmunotherapylivernatural killer cells

Identifiers

PMID39907091
PMCPMC11459526

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.