Evidence map›Paper›PMID 39906934›Full record

ArticleHistology and histopathology2025

Clinical significance of ALDH1A1 and Ki67 expression in women with breast carcinoma.

Yuxuan Zong, Shuang Ma, Jiaxin Yin, Na Qiao, Dongmei Zhang, Zhaoyang Niu, Ye Zhao, Fei Zhou

Abstract read
PubMed Publisher
In one paragraph

Article in Histology and histopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuxuan ZongDepartment of Second Breast Surgery, Southern Hospital of Qiqihar First Hospital, Longsha, Qiqihar, Heilongjiang, PR China.
Shuang MaDepartment of Second Breast Surgery, Southern Hospital of Qiqihar First Hospital, Longsha, Qiqihar, Heilongjiang, PR China.
Jiaxin YinDepartment of Second Breast Surgery, Southern Hospital of Qiqihar First Hospital, Longsha, Qiqihar, Heilongjiang, PR China.
Na QiaoDepartment of Second Breast Surgery, Southern Hospital of Qiqihar First Hospital, Longsha, Qiqihar, Heilongjiang, PR China.
Dongmei ZhangDepartment of Second Breast Surgery, Southern Hospital of Qiqihar First Hospital, Longsha, Qiqihar, Heilongjiang, PR China.
Zhaoyang NiuDepartment of Second Breast Surgery, Southern Hospital of Qiqihar First Hospital, Longsha, Qiqihar, Heilongjiang, PR China.
Ye ZhaoDepartment of Second Breast Surgery, Southern Hospital of Qiqihar First Hospital, Longsha, Qiqihar, Heilongjiang, PR China.
Fei ZhouDepartment of Second Breast Surgery, Southern Hospital of Qiqihar First Hospital, Longsha, Qiqihar, Heilongjiang, PR China. zhoufei789@outlook.com.

Funding

Heilongjiang Province Natural Science Foundation LH2023H103
6 · The paper itself

Abstract

backgroundBreast cancer is the most prominent cancer among women worldwide, with a two-fold incidence in China compared to the worldwide incidence. ALDH1A1, catalyzing the oxidation of intracellular aldehydes and converting retinol into retinoic acid, serves as a biomarker of early stem cell differentiation. Ki67 levels are prognostic or residual risk biomarkers after primary therapy and can predict the effects of systemic therapies or monitor patients for sustained response or resistance to the administered therapies. This study aimed to investigate the correlation between ALDH1A1 and Ki67 expression and clinicopathological parameters among women with breast cancer.

methodsBreast cancer tissue specimens were obtained from the Department of Pathology at the First Hospital of Qiqihar. Indirect fluorescent immunostaining was used to assess the expression of ALDH1A1 and Ki67 in breast cancer and healthy tissues. Associations between ALDH1A1 and Ki67 expression and clinicopathological parameters of breast cancer were evaluated using the chi-square test. A

resultsALDH1A1 and Ki67 were upregulated in breast cancer tissue compared with normal breast tissue (

conclusionALDH1A1 may be considered a pathognomonic marker for breast cancer. ALDH1A1 and Ki67 expression are significantly positively correlated in women with breast cancer.

Indexed as

Biomarkers, TumorBreast NeoplasmsKi-67 AntigenAdultAgedAldehyde Dehydrogenase 1 FamilyClinical RelevanceFemaleHumansImmunohistochemistryMiddle AgedRetinal DehydrogenaseAldehyde Dehydrogenase 1 FamilyALDH1A1 protein, humanBiomarkers, TumorKi-67 AntigenMKI67 protein, humanRetinal Dehydrogenase

Identifiers

PMID39906934

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.