Evidence map›Paper›PMID 39906900›Full record

ArticleJCEM case reports2025

A Novel and Rare Pathogenic Gene Variant in 2 Patients With Multiple Endocrine Neoplasia Type 1 (MEN-1) Syndrome.

Jordan C LeSarge, Hani Rjoob, Kristin K Clemens, Stan Van Uum, Laila C Schenkel, Tayyab S Khan

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JCEM case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jordan C LeSargeDepartment of Medicine, Schulich School of Medicine & Dentistry, Western University and London Health Sciences Centre, London, ON, Canada N6A 5W9.
Hani RjoobCollege of Medicine and Health Sciences, Palestine Polytechnic University, Hebron 198, Palestinian Territories.
Kristin K ClemensDepartment of Medicine, Schulich School of Medicine & Dentistry, Western University and London Health Sciences Centre, London, ON, Canada N6A 5W9.
Stan Van UumDepartment of Medicine, Schulich School of Medicine & Dentistry, Western University and London Health Sciences Centre, London, ON, Canada N6A 5W9.ORCID https://orcid.org/0000-0002-0150-8223
Laila C SchenkelMolecular Diagnostics Division, Molecular Genetics Laboratory, London Health Sciences Centre, London, ON, Canada N6A3K7.
Tayyab S KhanDepartment of Medicine, Schulich School of Medicine & Dentistry, Western University and London Health Sciences Centre, London, ON, Canada N6A 5W9.ORCID https://orcid.org/0000-0002-1713-8781

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple endocrine neoplasia type 1 (MEN-1) is a syndrome characterized by development of tumors including parathyroid adenomas, duodenopancreatic neuroendocrine tumors, and pituitary adenomas. We describe 1 patient with a novel and another with a rare pathogenic MEN-1 variant. Case 1 was a 61-year-old woman with recurrent hypercalcemia who ultimately required a subtotal parathyroidectomy, with a thymectomy revealing a thymoma. She then developed a gastrinoma requiring pancreatectomy and also had a biochemically nonfunctioning sellar mass. Genetic testing found a novel

Indexed as

duodeno-pancreatic neuroendocrine tumor (NET)multiple endocrine neoplasia type 1 (MEN-1)novel pathogenic variantparathyroid adenomapituitary adenomathymoma

Identifiers

PMID39906900
PMCPMC11791340

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.