Evidence map›Paper›PMID 39906720›Full record

ArticleFrontiers in allergy2024

Exploring the potential mediating role of systemic antibiotics in the association between early-life lower respiratory tract infections and asthma at age 5 in the CHILD study.

Maria V Medeleanu, Myrtha E Reyna, Darlene L Y Dai, Geoffrey L Winsor, Fiona S L Brinkman, Rahul Verma, Ella Nugent, Nashita Riaz, Elinor Simons, Piushkumar J Mandhane and 4 more

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In one paragraph

Article in Frontiers in allergy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maria V MedeleanuTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Myrtha E ReynaTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Darlene L Y DaiDepartment of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.
Geoffrey L WinsorDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
Fiona S L BrinkmanDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
Rahul VermaDivision of Respiratory Medicine, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Ella NugentTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Nashita RiazTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Elinor SimonsDepartment of Pediatrics and Child Health, Section of Allergy and Immunology, University of Manitoba, Winnipeg, MB, Canada.
Piushkumar J MandhaneDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Meghan B AzadManitoba Interdisciplinary Lactation Centre (MILC), Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.
Stuart E TurveyDepartment of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.
Theo J MoraesTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Padmaja Subbarao *Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Lower respiratory tract infections (LRTIs) in early life are one of the strongest risk factors for childhood asthma and are often treated with systemic antibiotics (IV or oral). We aimed to explore the association between early-life LRTIs and systemic antibiotics on asthma development and the potential mediating role of antibiotics in this relationship. Methods: Data were collected as part of the longitudinal, general Canadian population CHILD Study. LRTIs during the first 18 months of life were identified through parental symptom report at regular study visits. Systemic antibiotic use was defined as at least one dose of oral/intravenous antibiotics between birth and the 18-month visit and were further categorized by indication as either given for a respiratory indication (upper or lower respiratory symptoms) or non-respiratory indication. Asthma was diagnosed by in-study pediatricians at the 5-year study visit. Adjusted logistic regression models and mediation analyses via systemic antibiotics use were performed. Results: Among 2,073 participants included in our analysis, 72 (4.9%) had asthma age 5, and 609 (29.3%) used systemic antibiotics before the 18-month visit. Among children who had taken antibiotics, 61.6% also had an LRTI in that period compared to 49.7% among children without exposure to systemic antibiotics ( Conclusion: Through mediation modeling we estimate that the increased risk of asthma at age 5 that is associated with moderate-severe LRTIs in infancy may be partially mediated by systemic antibiotics taken during the first 18 months of life. This underscores the importance of public health strategies focused on antibiotic stewardship and reducing early life LRTIs to mitigate asthma risk.

Indexed as

antibioticsclinical epidemiologycohort studymediation analysespreschool asthmarespiratory tract infections

Identifiers

PMID39906720
PMCPMC11790586

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.