Evidence map›Paper›PMID 39906711›Full record

ArticleCommunicative & integrative biology2025

Structure simulation-based comparison of active site variations in fungal ornithine decarboxylases.

Min Jeong Kim, Jeong Ho Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communicative & integrative biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Min Jeong KimDepartment of Biology Education, Kyungpook National University, Daegu, South Korea.
Jeong Ho ChangDepartment of Biology Education, Kyungpook National University, Daegu, South Korea.ORCID https://orcid.org/0000-0002-2126-0317

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyamines play crucial roles in various biological processes, including cell proliferation and differentiation, immune response modulation, and signal transduction. Ornithine decarboxylase (ODC) initiates polyamine biosynthesis by catalyzing the conversion of ornithine to putrescine in a pyridoxal phosphate (PLP)-dependent manner. While the structures of mammalian and protozoan ODCs have been elucidated, fungal ODCs remain uncharacterized. In this study, AlphaFold2 was employed to simulate the structures of ODCs from four fungi:

Indexed as

Candida albicansDebaryomyces hanseniiKluyveromyces lactisornithine decarboxylasePLP-dependent enzymepolyamineSchizosaccharomyces pombespecificity helix

Identifiers

PMID39906711
PMCPMC11792860

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.