Evidence map›Paper›PMID 39906690›Full record

ArticleJournal of pharmaceutical analysis2025

Discovery of E0199: A novel compound targeting both peripheral Na

Boxuan Zhang, Xiaoxing Shi, Xingang Liu, Yan Liu, Xuedong Li, Qi Wang, Dongyang Huang, Weidong Zhao, Junru Cui, Yawen Cao and 5 more

Abstract read
In one paragraph

Article in Journal of pharmaceutical analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. KCommunications medicine · 2026
    Article
  3. Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Boxuan ZhangDepartment of Pharmaceutical Chemistry, College of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, China.
Xiaoxing ShiDepartment of Pharmacology, College of Basic Medical, Hebei Medical University, Shijiazhuang, 050017, China.
Xingang LiuDepartment of Pharmaceutical Chemistry, College of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, China.
Yan LiuDepartment of Pharmaceutical Experimental Teaching Center, College of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, China.
Xuedong LiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, China.
Qi WangShijiazhuang Xianyu Digital Biotechnology Co., Ltd., College of Software, Hebei Normal University, Shijiazhuang, 050024, China.
Dongyang HuangDepartment of Pharmacology, College of Basic Medical, Hebei Medical University, Shijiazhuang, 050017, China.
Weidong ZhaoDepartment of Pharmacology, College of Basic Medical, Hebei Medical University, Shijiazhuang, 050017, China.
Junru CuiThe Center for New Drug Safety Evaluation and Research, Hebei Medical University, Shijiazhuang, 050017, China.
Yawen CaoDepartment of Pharmacology, College of Basic Medical, Hebei Medical University, Shijiazhuang, 050017, China.
Xu ChaiDepartment of Pharmacology, College of Basic Medical, Hebei Medical University, Shijiazhuang, 050017, China.
Jiahao WangDepartment of Pharmacology, College of Basic Medical, Hebei Medical University, Shijiazhuang, 050017, China.
Yang ZhangDepartment of Pharmaceutical Chemistry, College of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, China.
Xiangyu WangHebei Medical University Postdoctoral Mobile Station of Basic Medical, Hebei Medical University, Shijiazhuang, 050017, China.
Qingzhong JiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This research study focuses on addressing the limitations of current neuropathic pain (NP) treatments by developing a novel dual-target modulator, E0199, targeting both Na

Indexed as

Dorsal root gangliaKV7 channelNaV channelNeuropathic pain

Identifiers

PMID39906690
PMCPMC11791318

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.