Evidence map›Paper›PMID 39906676›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2025

Feasibility, Usability, and Pilot Efficacy Study of a Software-Enabled, Virtual Pulmonary Rehabilitation with Remote Therapeutic Monitoring.

Sheryl Flynn, Christopher L Mosher, Sharon Cornelison, Erica Rao, Kimberly A Metzler, William Pu, John Davies, Connie Paladenech, Daniel Doyle, Neil MacIntyre and 1 more

Abstract readComparative Study
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Geriatric respiratory medicine 2026: from artificial intelligence to personalised management of the multimorbid patient.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  2. Article
  3. Who Enrolls After Referral to Virtual Pulmonary Rehabilitation? A Descriptive Comparison.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sheryl FlynnBlue Marble Health, Altadena, California, USA.ORCID 0000-0003-1726-8540
Christopher L MosherDivision of Pulmonary, Allergy, and Critical Care Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Sharon CornelisonDepartment of Cardiac and Pulmonary Rehabilitation, J. Paul Sticht Center on Aging and Rehabilitation, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.
Erica RaoDivision of Pulmonary, Allergy, and Critical Care Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Kimberly A MetzlerDepartment of Cardiac and Pulmonary Rehabilitation, J. Paul Sticht Center on Aging and Rehabilitation, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.
William PuBlue Marble Health, Altadena, California, USA.ORCID 0009-0009-5744-1804
John DaviesDivision of Pulmonary, Allergy, and Critical Care Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Connie PaladenechDepartment of Cardiac and Pulmonary Rehabilitation, J. Paul Sticht Center on Aging and Rehabilitation, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.
Daniel DoyleDuke Clinical Research Institute, Durham, North Carolina, United States; 3Cabin Creek Health Systems, Dawes, West Virginia, USA.
Neil MacIntyreDivision of Pulmonary, Allergy, and Critical Care Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Jill OharWake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0002-2757-6806

Funding

Inspiration Point-A Digital Pulmonary Rehabilitation Tool for use with Self-Management InterventionsR44HL137502 · NHLBI · BLUE MARBLE REHAB, INC. · PI FLYNN, SHERYL · 2017 to 2019
$1.7M
NHLBI NIH HHS R44 HL137502
6 · The paper itself

Abstract

Objective: Fewer than 3% of adults with Chronic Obstructive Pulmonary Disease (COPD) attend in-person, center-based pulmonary rehabilitation (PR) despite demonstrated health benefits and reduction in mortality. This study evaluated the feasibility and usability of a novel home-based, virtual PR (V-PR) intervention compared to center-based PR (C-PR). The virtual PR intervention was supported by remote therapeutic monitoring (V-PR+RTM; Blue Marble Platform, Blue Marble Health, Altadena, CA). Additionally, we collected data on the 6-Minute Walk Test to explore the efficacy of the V-PR compared to C-PR. Patients and Methods: Adults with stable COPD referred for PR were recruited. The participants self-selected C-PR or V-PR and were provided a 6-8-week personalized exercise and COPD self-management educational program. In addition, weekly phone contacts with the V-PR group were made. Feasibility was measured using qualitative analysis of adherence, reasons for withdrawal, and self-reported barriers to using the software at home. Usability was measured with the System Usability Scale (SUS). Efficacy was evaluated with the 6 minute Walk Test (6MWT) and various functional performance and patient-centered health-related quality of life (HRQoL) questionnaires. Results: Forty-eight participants were enrolled, and 40 (83.3%) completed the intervention, n=17 in the C-PR group and n=23 in the V-PR group. Four participants from each group withdrew due to reasons related to health issues (appendicitis, thrush, COVID, back pain) or the health status of their spouse, no-shows, and time constraints. Adherence to the exercise dose (3x/week) and educational offerings were >80% in both groups. Participants in the V-PR group scored the software as having high usability. In both groups, 6MWT distance improved significantly, as did scores on the CAT and SGRQ. No adverse events were reported in either group. Conclusion: A software-enabled virtual PR program with remote therapeutic monitoring is feasible, usable, and effective. It could offer an alternative model that increases PR uptake for those unable or unwilling to attend in-person, center-based PR.

Indexed as

Exercise TherapyLungPulmonary Disease, Chronic ObstructiveSoftwareAgedExercise ToleranceFeasibility StudiesFemaleFunctional StatusHumansMaleMiddle AgedPatient CompliancePatient Education as TopicPilot ProjectsPredictive Value of Testschronic obstructive pulmonary diseaseCOPDeducationexercise trainingpulmonary rehabilitationremote therapeutic monitoringself-managementtelehealthvirtual

Identifiers

PMID39906676
PMCPMC11792638

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.