Evidence map›Paper›PMID 39906639›Full record

ArticleRSC advances2025

Development of a scalable and sustainable continuous-flow microreaction process for mononitration of aromatic compounds with high selectivity and yield.

Dong Xing, Xiangui Lei, Yufeng Fu, Zhijie Xu, Dengyun Luo, Jiujun Chen, Yong Xiang, Zhouyu Wang, Qiao Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dong XingSichuan Engineering Research Center for Molecular Targeted Diagnostic & Therapeutic Drugs, Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province, Research and Application of Small Organic Chiral Molecules Key Laboratory of Yibin City, Department of Chemistry, Xihua University Chengdu 610039 China songqiao@xhu.edu.cn zhouyuwang@mail.xhu.edu.cn.ORCID https://orcid.org/0009-0009-7581-1872
Xiangui LeiSichuan Engineering Research Center for Molecular Targeted Diagnostic & Therapeutic Drugs, Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province, Research and Application of Small Organic Chiral Molecules Key Laboratory of Yibin City, Department of Chemistry, Xihua University Chengdu 610039 China songqiao@xhu.edu.cn zhouyuwang@mail.xhu.edu.cn.
Yufeng FuSichuan Engineering Research Center for Molecular Targeted Diagnostic & Therapeutic Drugs, Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province, Research and Application of Small Organic Chiral Molecules Key Laboratory of Yibin City, Department of Chemistry, Xihua University Chengdu 610039 China songqiao@xhu.edu.cn zhouyuwang@mail.xhu.edu.cn.
Zhijie XuSichuan Engineering Research Center for Molecular Targeted Diagnostic & Therapeutic Drugs, Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province, Research and Application of Small Organic Chiral Molecules Key Laboratory of Yibin City, Department of Chemistry, Xihua University Chengdu 610039 China songqiao@xhu.edu.cn zhouyuwang@mail.xhu.edu.cn.
Dengyun LuoSichuan Engineering Research Center for Molecular Targeted Diagnostic & Therapeutic Drugs, Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province, Research and Application of Small Organic Chiral Molecules Key Laboratory of Yibin City, Department of Chemistry, Xihua University Chengdu 610039 China songqiao@xhu.edu.cn zhouyuwang@mail.xhu.edu.cn.
Jiujun ChenSichuan North Hongguang Special Chemical Co., Ltd, Yinguang Group Yibin 644000 China.
Yong XiangSichuan North Hongguang Special Chemical Co., Ltd, Yinguang Group Yibin 644000 China.
Zhouyu WangSichuan Engineering Research Center for Molecular Targeted Diagnostic & Therapeutic Drugs, Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province, Research and Application of Small Organic Chiral Molecules Key Laboratory of Yibin City, Department of Chemistry, Xihua University Chengdu 610039 China songqiao@xhu.edu.cn zhouyuwang@mail.xhu.edu.cn.
Qiao SongSichuan Engineering Research Center for Molecular Targeted Diagnostic & Therapeutic Drugs, Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province, Research and Application of Small Organic Chiral Molecules Key Laboratory of Yibin City, Department of Chemistry, Xihua University Chengdu 610039 China songqiao@xhu.edu.cn zhouyuwang@mail.xhu.edu.cn.ORCID https://orcid.org/0000-0001-5752-652X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitroaromatic compounds are extensively used in industries such as pharmaceuticals, pesticides, and dyes. However, traditional synthesis methods often face challenges, including high safety risks, significant environmental pollution, and poor selectivity in mononitration reactions. In this study, we developed an efficient and safe continuous-flow microreaction process for mononitration, which achieves high yield and excellent selectivity. This process is applicable for the continuous synthesis of various mononitro compounds, including nitro-

Identifiers

PMID39906639
PMCPMC11791747

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.