Evidence map›Paper›PMID 39906636›Full record

ArticleRSC advances2025

Discovery of new benzothiazole-1,2,3-triazole hybrid-based hydrazone/thiosemicarbazone derivatives as potent EGFR inhibitors with cytotoxicity against cancer.

Ateyatallah Aljuhani, Mohamed S Nafie, Nader R Albujuq, Mosa Alsehli, Sanaa K Bardaweel, Khaled M Darwish, Shaya Y Alraqa, Mohamed Reda Aouad, Nadjet Rezki

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Click synthesis of some novel benzo[RSC medicinal chemistry · 2025
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ateyatallah AljuhaniChemistry Department, College of Sciences, Taibah University Al-Madinah Al-Munawarah 41477 Saudi Arabia ateyatallah@hotmail.com mosa_alsehli@hotmail.com Sqahtani@taibahu.edu.sa aouadmohamedreda@yahoo.fr nadjetrezki@yahoo.fr.
Mohamed S NafieDepartment of Chemistry, College of Sciences, University of Sharjah P.O. 27272 Sharjah United Arab Emirates mohamed.elsayed@sharjah.ac.ae.ORCID https://orcid.org/0000-0003-4454-6390
Nader R AlbujuqDepartment of Chemistry, School of Science, The University of Jordan Amman 11942 Jordan n.albujuq@ju.edu.jo.ORCID https://orcid.org/0000-0002-3089-7037
Mosa AlsehliChemistry Department, College of Sciences, Taibah University Al-Madinah Al-Munawarah 41477 Saudi Arabia ateyatallah@hotmail.com mosa_alsehli@hotmail.com Sqahtani@taibahu.edu.sa aouadmohamedreda@yahoo.fr nadjetrezki@yahoo.fr.
Sanaa K BardaweelDepartment of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan Amman 11942 Jordan s.bardaweel@ju.edu.jo.ORCID https://orcid.org/0000-0002-4823-0708
Khaled M DarwishMedicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University Ismailia 41522 Egypt khaled_darwish@pharm.suez.edu.eg.ORCID https://orcid.org/0000-0002-0597-482X
Shaya Y AlraqaChemistry Department, College of Sciences, Taibah University Al-Madinah Al-Munawarah 41477 Saudi Arabia ateyatallah@hotmail.com mosa_alsehli@hotmail.com Sqahtani@taibahu.edu.sa aouadmohamedreda@yahoo.fr nadjetrezki@yahoo.fr.
Mohamed Reda AouadChemistry Department, College of Sciences, Taibah University Al-Madinah Al-Munawarah 41477 Saudi Arabia ateyatallah@hotmail.com mosa_alsehli@hotmail.com Sqahtani@taibahu.edu.sa aouadmohamedreda@yahoo.fr nadjetrezki@yahoo.fr.ORCID https://orcid.org/0000-0001-7018-6654
Nadjet RezkiChemistry Department, College of Sciences, Taibah University Al-Madinah Al-Munawarah 41477 Saudi Arabia ateyatallah@hotmail.com mosa_alsehli@hotmail.com Sqahtani@taibahu.edu.sa aouadmohamedreda@yahoo.fr nadjetrezki@yahoo.fr.ORCID https://orcid.org/0000-0001-8330-1738

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considering the widespread availability of certain medicines, there is still a critical need for potent anti-cancer agents. It is owing to numerous negative impacts and non-functionality of current drugs, particularly during the late stages of illness. To accomplish this, the new array of 1,2,3-triazole-benzothiazole molecular conjugates tethering hydrazone/thiosemicarbazone linkage 8a-l have been successfully synthesized

Identifiers

PMID39906636
PMCPMC11792500

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.