Evidence map›Paper›PMID 39906575›Full record

ArticleLaryngoscope investigative otolaryngology2025

Multiple Mutations-A Genetic Marker for Extracapsular Spread in Human Papillomavirus/p16-Positive Oropharyngeal Carcinoma.

Raphaela Graessle, Iris Piwonski, Cora Husemann, Karsten Kleo, Deema Sabtan, Achim Franzen, Heidi Olze, Ulrike Erben, Michael Hummel, Annekatrin Coordes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Raphaela GraessleDepartment of Otorhinolaryngology - Head and Neck Surgery University Hospital Ruppin-Brandenburg, Brandenburg Medical School Theodor Fontane (MHB) Neuruppin Germany.ORCID https://orcid.org/0009-0007-2677-2921
Iris PiwonskiDepartment of Pathology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin Humboldt-Universität zu Berlin, and Berlin Institute of Health Berlin Germany.
Cora HusemannDepartment of Pathology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin Humboldt-Universität zu Berlin, and Berlin Institute of Health Berlin Germany.
Karsten KleoDepartment of Pathology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin Humboldt-Universität zu Berlin, and Berlin Institute of Health Berlin Germany.
Deema SabtanDepartment of Pathology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin Humboldt-Universität zu Berlin, and Berlin Institute of Health Berlin Germany.
Achim FranzenDepartment of Otorhinolaryngology - Head and Neck Surgery University Hospital Ruppin-Brandenburg, Brandenburg Medical School Theodor Fontane (MHB) Neuruppin Germany.
Heidi OlzeDepartment of Otorhinolaryngology, Head and Neck Surgery, Campus Virchow Klinikum and Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Freie Universität Berlin Humboldt-Universität zu Berlin, and Berlin Institute of Health Berlin Germany.
Ulrike ErbenFaculty of Health Sciences Brandenburg, Joint Faculty of the University of Potsdam Brandenburg University of Technology Cottbus-Senftenberg and Brandenburg Medical School Potsdam Germany.
Michael HummelDepartment of Pathology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin Humboldt-Universität zu Berlin, and Berlin Institute of Health Berlin Germany.
Annekatrin CoordesDepartment of Otorhinolaryngology - Head and Neck Surgery University Hospital Ruppin-Brandenburg, Brandenburg Medical School Theodor Fontane (MHB) Neuruppin Germany.ORCID https://orcid.org/0000-0003-3520-0638

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In the 8th edition of the TNM classification, extracapsular spread (ECS) became a factor in classifying the UICC stage of oropharyngeal carcinomas (OPSCC). We aimed to find genetic markers for ECS and to identify differences between HPV/p16-positive and HPV/p16-negative cases. Methods: We performed targeted next-generation sequencing on 99 samples of operable OPSCC and a retrospective analysis of clinical data. Results: We included 55 HPV/p16-positive and 44 HPV/p16-negative patients. We found a significant difference between both groups, particularly in TP53 mutation ( Conclusion: The presence of multiple mutations in HPV+/p16+ OPSCC was associated with a higher risk of ECS. Level of Evidence: 3.

Indexed as

extracapsular spreadHPVoropharyngeal carcinomaPTENsomatic mutations

Identifiers

PMID39906575
PMCPMC11791759

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.