Evidence map›Paper›PMID 39906560›Full record

ArticleiScience2025

Super-enhancers and efficacy of triptolide in small cell carcinoma of the ovary hypercalcemic type.

Jessica D Lang, William Selleck, Shawn Striker, Nicolle A Hipschman, Rochelle Kofman, Anthony N Karnezis, Felix K F Kommoss, Friedrich Kommoss, Jae Rim Wendt, Salvatore J Facista and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jessica D LangDivision of Integrated Cancer Genomics, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
William SelleckDivision of Integrated Cancer Genomics, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Shawn StrikerDivision of Integrated Cancer Genomics, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Nicolle A HipschmanDivision of Integrated Cancer Genomics, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Rochelle KofmanDivision of Integrated Cancer Genomics, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Anthony N KarnezisDepartment of Pathology and Laboratory Medicine, University of California Davis, Sacramento, CA 95817, USA.
Felix K F KommossInstitute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Friedrich KommossInstitute of Pathology, Medizin Campus Bodensee, 88048 Friedrichshafen, Germany.
Jae Rim WendtDepartment of Pathology and Laboratory Medicine, UW Carbone Cancer Center, and Center for Human Genomics and Precision Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
Salvatore J FacistaDivision of Integrated Cancer Genomics, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
William P D HendricksDivision of Integrated Cancer Genomics, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Krystal A OrlandoDepartment of Pathology and Laboratory Medicine, and the Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
Patrick PirrotteCollaborative Center for Translational Mass Spectrometry, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Elizabeth A RaupachDivision of Integrated Cancer Genomics, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Victoria L ZismannDivision of Integrated Cancer Genomics, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Yemin WangDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z7, Canada.
David G HuntsmanDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z7, Canada.
Bernard E WeissmanDepartment of Pathology and Laboratory Medicine, and the Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
Jeffrey M TrentDivision of Integrated Cancer Genomics, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.

Funding

The Tumor Suppressor Role of SMARCA4 in SCCOHTR01CA195670 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HUNTSMAN, DAVID, TRENT, JEFFREY M. · 2015 to 2019
$3.7M
Characterization of the role of super-enhancers in ovarian cancer treatment responseR00CA234391 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI LANG, JESSICA DIANE · 2021 to 2023
$744k
Characterization of the role of super-enhancers in ovarian cancer treatment responseK99CA234391 · NCI · TRANSLATIONAL GENOMICS RESEARCH INST · PI LANG, JESSICA DIANE · 2019 to 2020
$223k
NCI NIH HHS K99 CA234391NCI NIH HHS R00 CA234391NCI NIH HHS R01 CA195670
6 · The paper itself

Abstract

Small cell carcinoma of the ovary-hypercalcemic type (SCCOHT) is a rare ovarian cancer affecting young females and is driven by the loss of both SWI/SNF ATPases SMARCA4 and SMARCA2. As loss of SWI/SNF alters enhancers, we hypothesized that super-enhancers, which regulate oncogene expression in cancer, are disparately impacted by SWI/SNF loss. We discovered differences between SWI/SNF occupancy at enhancers vs. super-enhancers. SCCOHT super-enhancer target genes were enriched in developmental processes, most notably nervous system development. This may further support neuronal cell-of-origin previously proposed. We found high sensitivity of SCCOHT cell lines to triptolide. Triptolide inhibits expression of many super-enhancer-associated genes, including oncogenes.

Indexed as

CancerComplex system biologyMolecular biology

Identifiers

PMID39906560
PMCPMC11791298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.