ArticleiScience2025
A 5-transcript signature for discriminating viral and bacterial etiology in pediatric pneumonia.
Abstract read
In one paragraph
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Classification of pulmonary inflammation stages and assessment of multicomponent drug intervention based on spatiotemporal imaging variations utilizing RhB-conjugated poly-L-lysine nanoparticles.Journal of pharmaceutical analysis · 2026Article
- Article
- Tudor domain-containing protein 9-targeting siRNA nanoparticles alleviate Pseudomonas aeruginosa lung injury in preclinical models by promoting neutrophil cuproptosis.Nature communications · 2026Article
- From genes to clinical application: a circulating four-gene signature for early diagnosis model of refractoryFrontiers in cellular and infection microbiology · 2026Article
- A four-gene signature from blood to exclude bacterial etiology of lower respiratory tract infection in adults.Nature communications · 2025Article
- Diagnostic testing and antibiotic stewardship for pneumonia in children worldwide: current developments and next steps.Current opinion in pediatrics · 2025Review
- Fever in Children with Cancer: Pathophysiological Insights Using Blood Transcriptomics.International journal of molecular sciences · 2025Article
- A diagnostic host-specific transcriptome response for Mycoplasma pneumoniae pneumonia to guide pediatric patient treatment.Nature communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
45 authors.
Sandra Viz-LasherasUnidade de Xenética, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, and Genética de Poblaciones en Biomedicina (GenPoB) Research Group, Instituto de Investigación Sanitaria (IDIS), 15706 Hospital Clínico Universitario de Santiago (SERGAS), Galicia, Spain.
Alberto Gómez-CarballaUnidade de Xenética, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, and Genética de Poblaciones en Biomedicina (GenPoB) Research Group, Instituto de Investigación Sanitaria (IDIS), 15706 Hospital Clínico Universitario de Santiago (SERGAS), Galicia, Spain.
Jacobo Pardo-SecoUnidade de Xenética, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, and Genética de Poblaciones en Biomedicina (GenPoB) Research Group, Instituto de Investigación Sanitaria (IDIS), 15706 Hospital Clínico Universitario de Santiago (SERGAS), Galicia, Spain.
Xabier BelloUnidade de Xenética, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, and Genética de Poblaciones en Biomedicina (GenPoB) Research Group, Instituto de Investigación Sanitaria (IDIS), 15706 Hospital Clínico Universitario de Santiago (SERGAS), Galicia, Spain.
Irene Rivero-CalleGenetics, Vaccines and Infections Research Group (GenViP), Instituto de Investigación Sanitaria de Santiago, 15706 Universidade de Santiago de Compostela, Santiago de Compostela, Galicia, Spain.
Ana Isabel DacostaGenetics, Vaccines and Infections Research Group (GenViP), Instituto de Investigación Sanitaria de Santiago, 15706 Universidade de Santiago de Compostela, Santiago de Compostela, Galicia, Spain.
Myrsini KaforouDepartment of Infectious Disease, Imperial College London, London W2 1PG, UK.
Dominic Habgood-CooteDepartment of Infectious Disease, Imperial College London, London W2 1PG, UK.
Aubrey J CunningtonDepartment of Infectious Disease, Imperial College London, London W2 1PG, UK.
Marieke EmontsGreat North Children's Hospital, Paediatric Immunology, Infectious Diseases & Allergy, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK.
Jethro A HerbergDepartment of Infectious Disease, Imperial College London, London W2 1PG, UK.
Victoria J WrightDepartment of Infectious Disease, Imperial College London, London W2 1PG, UK.
Enitan D CarrolDepartment of Infectious Diseases, Alder Hey Children's NHS Foundation Trust, Liverpool L12 2AP, UK.
Stephane C PaulusDepartment of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford OX3 9DU, UK.
Werner ZenzDepartment of General Paediatrics, Medical University of Graz, Graz, Auenbruggerplatz 34/2 8036, Graz, Austria.
Daniela S KohlfürstDepartment of General Paediatrics, Medical University of Graz, Graz, Auenbruggerplatz 34/2 8036, Graz, Austria.
Michiel Van der FlierPediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht 3508 AB, the Netherlands.
Ronald de GrootPediatric Infectious Diseases and Immunology, Amalia Children's Hospital, and Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen 6500 HB, the Netherlands.
Luregn J SchlapbachDepartment of Intensive Care and Neonatology, and Children's Research Center, University Children's Hospital Zürich, University of Zürich, Zürich, Switzerland.
Philipp AgyemanDepartment of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Andrew J PollardDepartment of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford OX3 9DU, UK.
Colin FinkMicropathology Ltd, University of Warwick, Warwick CV4 7EZ, UK.
Taco T KuijpersDivision of Pediatric Immunology, Rheumatology and Infectious diseases, Emma Children's Hospital, Amsterdam Univiersyt Medical Center (Amsterdam UMC), Amsterdam 1105 AZ, the Netherlands.
Suzanne AndersonMedical Research Council Unit at the London School of Hygiene & Tropical Medicine, Banjul, The Gambia.
Cristina CalvoGeneral Pediatrics, Infectious and Tropical Diseases Department, Hospital La Paz, 28046 Madrid, Spain.
María Del Carmen Martínez-PadillaUnidad de Cuidados Intensivos Pediátricos, Complejo Hospitalario de Jaen, Jaen, Spain.
Ana Pérez-AragónHospital Universitario Virgen de las Nieves, Servicio de Pediatría, Granada, Spain.
Esteban Gómez-SánchezDepartment of Pediatric Intensive Care Unit, Hospital Universitario de Burgos, Burgos, Spain.
Juan Valencia-RamosDepartment of Pediatric Intensive Care Unit, Hospital Universitario de Burgos, Burgos, Spain.
Francisco Giménez-SánchezInstituto Hispalense de Pediatría, Instituto Balmis de Vacunas, Almería, Spain.
Paula Alonso-QuintelaNeonatal Intensive Care Unit, Complejo Asistencial Universitario de León, León, Spain.
Laura Moreno-GalarragaDepartment of Pediatrics, Complejo Hospitalario de Navarra, Servicio Navarro de Salud, Pamplona, Spain.
Ulrich von BothInfectious Diseases, Department of Pediatrics, Dr von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany.
Marko PokornDivision of Paediatrics, University Medical Centre Ljubljana and Medical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Dace ZavadskaChildren's Clinical University Hospital, Rīga Stradins University, Rïga, Latvia.
María TsoliaSecond Department of Paediatrics, National and Kapodistrian University of Athens (NKUA), School of Medicine, Panagiotis & Aglaia, Kyriakou Children's Hospital, Athens, Greece.
Clementien L VermontDepartment of Pediatrics, Erasmus MC, Rotterdam, the Netherlands.
Henriëtte A MollDepartment of Pediatrics, Erasmus MC, Rotterdam, the Netherlands.
Michael LevinDepartment of Infectious Disease, Imperial College London, London W2 1PG, UK.
Federico Martinón-TorresGenetics, Vaccines and Infections Research Group (GenViP), Instituto de Investigación Sanitaria de Santiago, 15706 Universidade de Santiago de Compostela, Santiago de Compostela, Galicia, Spain.
Antonio SalasUnidade de Xenética, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, and Genética de Poblaciones en Biomedicina (GenPoB) Research Group, Instituto de Investigación Sanitaria (IDIS), 15706 Hospital Clínico Universitario de Santiago (SERGAS), Galicia, Spain.
EUCLIDS
DIAMONDS
GENDRES and
PERFORM consortia
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pneumonia stands as the primary cause of death among children under five, yet current diagnosis methods often result in inadequate or unnecessary treatments. Our research seeks to address this gap by identifying host transcriptomic biomarkers in the blood of children with definitive viral and bacterial pneumonia. We performed RNA sequencing on 192 prospectively collected whole blood samples, including 38 controls and 154 pneumonia cases, uncovering a 5-transcript signature (genes
Indexed as
Body substance sampleClinical microbiologyDiagnosticsPediatricsTranscriptomics
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.