Evidence map›Paper›PMID 39906513›Full record

ArticleGE Portuguese journal of gastroenterology2025

Abdominal Hypoperfusion and Acute Kidney Injury in the Critically Ill Patient with Liver Cirrhosis: A Prospective Cohort Study.

Rui Pereira, Diogo Lopes, Sara Brandão Machado, Luís Val-Flores, Fernando Caeiro, Rui Perdigoto, Paulo Alexandre Marcelino, Faouzi Saliba

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In one paragraph

Article in GE Portuguese journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rui PereiraUnidade de Cuidados Intensivos Polivalente 7 (UCIP7), Hospital Curry Cabral, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal.
Diogo LopesUnidade de Cuidados Intensivos Polivalente 7 (UCIP7), Hospital Curry Cabral, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal.
Sara Brandão MachadoUnidade de Cuidados Intensivos Polivalente 7 (UCIP7), Hospital Curry Cabral, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal.
Luís Val-FloresUnidade de Cuidados Intensivos Polivalente 7 (UCIP7), Hospital Curry Cabral, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal.
Fernando CaeiroServiço de Nefrologia, Hospital Curry Cabral, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal.
Rui PerdigotoUnidade de Transplantes, Hospital Curry Cabral, Centro Hospitalar Universitário Lisboa Central, Nova Medical School, Universidade Nova de Lisboa, Lisbon, Portugal.
Paulo Alexandre MarcelinoUnidade de Cuidados Intensivos Polivalente 4 (UCIP4), Hospital de Santa Marta, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal.
Faouzi SalibaAP-HP Hôpital Paul Brousse, Hepato-Biliary Center, INSERM Unit No 1193, Université Paris Saclay, Villejuif, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Reduced abdominal perfusion pressure (APP) is an underdiagnosed potential pathophysiological mechanism for acute kidney injury (AKI) in the patient with liver cirrhosis and ascites. This study aimed to analyze the prevalence of abdominal hypoperfusion (AhP) (APP <60 mm Hg) and the impact of APP on AKI in critically ill patients with liver cirrhosis. Methods: This was a post hoc analysis from a prospective cohort study set in a general ICU at a tertiary university hospital. Patients were recruited between October 2016 and December 2021. Acute renal failure (ARF) was defined by stage 3 AKI according to the International Club of Ascites. Results: Fifty-eight patients where included, with a mean age of 57 (±8.4) years, 79% were male, and 93% had acute-on-chronic liver failure at admission. The prevalence of AhP reached 75%, and 29% of cases had persisting AhP during the first week of ICU stay. Patients with baseline AhP had a higher 28-day mortality compared to those without AhP (respectively, 76% vs. 49%, Conclusion: Critically ill patients with liver cirrhosis presented a high prevalence of ARF, independently associated with higher baseline serum urea and WBC, and lower persisting APP. A structured clinical approach to optimize APP may reduce renal dysfunction in high-risk patients with cirrhosis.

Indexed as

Abdominal compartment syndromeAcute kidney injuryAcute-on-chronic liver failureLiver cirrhosis

Identifiers

PMID39906513
PMCPMC11790267

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.