ArticleCureus2025
Evaluation of Gingival Depigmentation Using Different Surgical Techniques and Prevention of Repigmentation With Vitamin C: A Clinical Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of randomized controlled trials: efficacy of vitamin C mesotherapy for gingival hyperpigmentation in adults.BMC oral health · 2025Pooled it
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Gingival depigmentation is a cosmetic periodontal plastic surgical procedure for removing or reducing unesthetic melanin hyperpigmentation-the reappearance of melanin pigmentation after gingival depigmentation has been reported. Vitamin C has been routinely used for the management of hyperpigmentation in dermatology. However, very few studies have been conducted on the use of Vitamin C for the management of gingival hyperpigmentation. Further, the use of Vitamin C to prevent the recurrence of pigmentation after its surgical removal has not been reported. Hence, the present study was conducted. Aim The aim of the study is to evaluate gingival depigmentation by different surgical techniques and the prevention of repigmentation using Vitamin C. Methods Sixty-four sites in subjects aged 20-45 years with chief complaints of black-looking gums were selected. Scaling and root planning were done. Gingival depigmentation was performed by scalpel at half the sites (32 sites) and by laser technique at the other half sites (32 sites) under adequate local anesthesia. The gingival pigmentation index (Dummett-Gupta oral pigmentation index (DOPI)), visual analog scale (VAS), and surface area of pigmentation were assessed. Vitamin C was administered two weeks after surgical depigmentation and then at monthly intervals for six months. Results There was a statistically significant decrease in the DOPI score, the surface area of pigmentation from baseline to one year (p < 0.000), and the VAS score at laser-treated sites as compared to scalpel-treated sites at one month (p < 0.000). Conclusion Laser depigmentation is minimally invasive and preferred. Recurrence of gingival melanin pigmentation can be minimized by the administration of Vitamin C.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.