ArticleCureus2025
Cerebral Toxoplasmosis Mimicking a Brain Neoplasm in an Inaugural HIV-Positive Patient: The Importance of Early Decision-Making and Background Assessment in the Emergency Department.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Movement Disorders in Toxoplasmosis: A Systematic Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Pooled it
- Cerebral toxoplasmosis: Parasitology, diagnosis, treatment, and prevention - a narrative review.Current research in parasitology & vector-borne diseases · 2026Review
- The Radiological Mimicry of Ring-Enhancing Lesions: Cerebral Toxoplasmosis Masquerading as Metastatic Disease.Cureus · 2025Article
- The Major Facilitator Superfamily Transporter HAP12 Is Critical inInternational journal of molecular sciences · 2025Article
- Massive Intracranial Lesion in an AIDS Patient: Diagnostic Challenge Between Brain Tumor and Toxoplasmic Encephalitis Resolved by Empirical Therapy.International medical case reports journal · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracranial lesions can present a diagnostic challenge in patients without previously known immunosuppression. When focal neurological signs and seizures occur in a patient with no established medical history, an expansive brain lesion may be initially interpreted as a neoplasm, influencing early clinical decisions regarding the extent of supportive measures. However, opportunistic infections, such as cerebral toxoplasmosis, should remain on the differential diagnosis - particularly after consideration of the patient's background and potential epidemiological risks. We present the case of a middle-aged woman of African origin who presented with new-onset seizures and a prolonged history of anorexia and weight loss. Initial neuroimaging suggested a primary or metastatic brain tumor, raising concerns regarding the patient's prognosis and the appropriateness of aggressive support in the emergency setting. The patient received corticosteroids and anticonvulsants in the emergency department (ED), with a subsequent need to start noninvasive ventilation. Further laboratory workup revealed the inaugural human immunodeficiency virus (HIV) and
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Registered trials
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