ArticleGigaByte (Hong Kong, China)2025
A practical DNA data storage using an expanded alphabet introducing 5-methylcytosine.
Article in GigaByte (Hong Kong, China), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- DNA Data Storage Architecture via Ligation of Dynamic DNA Bytes.Small methods · 2026Article
- ZAT-DNA enables DNA data storage with molecular-layer non-replicability.Nature communications · 2026Article
- A practical DNA data storage using an expanded alphabet introducing 5-methylcytosine.GigaByte (Hong Kong, China) · 2025Article
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Authors and funding
11 authors.
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Abstract
The DNA molecule is a promising next-generation data storage medium. Recently, it has been theoretically proposed that non-natural or modified bases can serve as extra molecular letters to increase the information density. However, this strategy is challenging due to the difficulty in synthesizing non-natural DNA sequences and their complex structure. Here, we described a practical DNA data storage transcoding scheme named R+ based on an expanded molecular alphabet that introduces 5-methylcytosine (5mC). We demonstrated its experimental validation by encoding one representative file into several 1.3∼1.6 kbps Availability and implementation: R+ is implemented in Python and the code is available under a MIT license at https://github.com/Incpink-Liu/DNA-storage-R_plus.
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