Evidence map›Paper›PMID 39906308›Full record

ArticlePreventive medicine reports2025

Cervical cancer screening: Impact of collection technique on human papillomavirus detection and genotyping.

Alisa P Young, Mutiya Olorunfemi, Leigh Morrison, Scott A Kelley, Anna Laurie, Anna McEvoy, Jill Schneiderhan, Julie Prussack, Marie Claire O'Dwyer, Pamela Rockwell and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Preventive medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Comparison of Human Papillomavirus Genotyping by Research vs. Clinical Assay for Two Self-Collection Devices.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Alisa P YoungDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Mutiya OlorunfemiDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Leigh MorrisonDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Scott A KelleyDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Anna LaurieDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Anna McEvoyDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Jill SchneiderhanDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Julie PrussackDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Marie Claire O'DwyerDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Pamela RockwellDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Philip ZazoveDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Jonathan GabisonDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Jane ChargotDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Kristina GallagherDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Ananda SenDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Dongru ChenDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Elizabeth A HaroDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Emma A ButcherDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Martha L AlvesDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Christelle El KhouryDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.
Melinda L DendrinosDepartment of Obstetrics and Gynecology, 1500 E Medical Center Dr # 9, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Nicole BrashearDepartment of Obstetrics and Gynecology, 1500 E Medical Center Dr # 9, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Roger SmithDepartment of Obstetrics and Gynecology, 1500 E Medical Center Dr # 9, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Richard W LiebermanDepartment of Obstetrics and Gynecology, 1500 E Medical Center Dr # 9, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Natalie SaundersDepartment of Obstetrics and Gynecology, 1500 E Medical Center Dr # 9, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Elizabeth CampbellDepartment of Obstetrics and Gynecology, 1500 E Medical Center Dr # 9, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Heather M WallineDepartment of Otolaryngology, 1500 E Medical Center Dr # 1 University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Diane M HarperDepartment of Family Medicine, University of Michigan Medical School, 300 North Ingalls Street, NI4C06, Ann Arbor, MI 48109, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The Food and Drug Administration (FDA) in the US approved primary human papillomavirus (HPV) testing for speculum-based cervical cancer screening ten years ago and, in May 2024, approved the self-collection technique. Our study defines the kappa agreement between self- and speculum-based collection techniques for 15 types of high-risk HPV. Additionally, we describe the sensitivity and specificity ratios for HPV testing using both collection methods. Methods: Participants recruited in 2020-2022 included 97 colposcopy attendees and 96 routine primary care screening attendees aged 30-65, who agreed to self-sample before their clinically scheduled speculum-based exam. Prevalence-based kappa calculated agreement, sensitivity and specificity ratios calculated accuracy using the cervical intraepithelial neoplasia grade 2 or worse (CIN 2+) threshold. Results: The average ages were 45.9 (SD 10.5) and 46.2 (SD 11.0) years for the colposcopy and primary care attendees, respectively. HPV 16, 68, and 39 were the most common types detected. The lower bound of the 95 % Cl for kappa calculations was above 0.81, indicating almost perfect agreement across all HPV genotypes. The sensitivity and specificity ratios were consistent at 1.0 across both collection methods. The HPV positivity rate was significantly higher among colposcopy attendees at 66 % (64/97), compared to 14 % (13/96) among routine primary care screeners. The study identified 17 women with CIN2 + . Conclusions: Primary HPV screening with self-collection is equivalent to speculum-based collection among people aged 30-65. The findings emphasize the utility of self-collection in identifying high-grade lesions and the consistency of HPV detection across different collection methods.

Indexed as

Agreement.Cervical cancer screeningKappa.Primary HPV screening.Self-sampling.Sensitivity.Specificity.

Identifiers

PMID39906308
PMCPMC11791345

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.