ArticleFrontiers in human neuroscience2024
Effect of continuous theta burst stimulation on the glymphatic system, brain network and cognitive function in patients with cerebral small vessel disease.
Article in Frontiers in human neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Impact of neurovascular coupling and glymphatic function on cognitive function in asymptomatic cerebral small vessel disease.Frontiers in neurology · 2026Article
- Glymphatic-meningeal lymphatic system imbalance: a peripheral-to-central inflammatory bridge in perioperative neurocognitive disorders.Frontiers in immunology · 2026Review
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Authors and funding
6 authors.
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Abstract
Objective: We aim to investigate the impact of continuous theta burst stimulation (cTBS) on glymphatic system (GS), brain network (BN) and cognition in cerebral small vessel disease (CSVD). Methods: This exploratory study included a small cohort of 11 patients, divided into a cTBS group (6 patients) and a sham-cTBS group (5 patients). Over a period of 2 weeks, all participants underwent cTBS to the right dorsolateral prefrontal cortex (DLPFC). The efficiency of the GS was assessed by along the perivascular space (ALPS) index. BN was measured using global efficiency (GE), characteristic path length (CPL) and clustering coefficient ( Results: In the cTBS group, the ALPS index increased 4 out of 6 after treatment, compared to an increase in only 2 out of 5 in the control. Improvements in GE, CPL and Conclusion: Applying cTBS to the DLPFC in CSVD may enhance the efficiency of brain glymphatic clearance, optimize network connectivity and improve cognitive function to a certain extent.
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