Evidence map›Paper›PMID 39906263›Full record

ArticleIEEE open journal of engineering in medicine and biology2025

The Shift to Over-the-Counter Diagnostic Testing After RADx: Clinical, Regulatory, and Societal Implications.

Maren Downing, John Broach, Wilbur Lam, Yukari C Manabe, Greg Martin, David McManus, Robert Murphy, Apurv Soni, Steven Schachter

Abstract read
In one paragraph

Article in IEEE open journal of engineering in medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maren DowningM Biomedical LLC McCormick SC 29835 USA.ORCID https://orcid.org/0000-0001-5121-4584
John BroachSchool of MedicineUMass Chan Worcester MA 01655 USA.
Wilbur LamDepartment of Pediatrics and the Wallace H. Coulter Department of Biomedical EngineeringEmory University School of Medicine and Georgia Institute of Technology Atlanta GA 30307 USA.
Yukari C ManabeDivision of Infectious Diseases, Department of MedicineJohns Hopkins University School of Medicine Baltimore MD 21205 USA.
Greg MartinDivision of Pulmonary, Allergy, Critical Care and Sleep MedicineEmory University School of Medicine Atlanta GA 30307 USA.
David McManusDivision of Cardiology, Department of MedicineUMAss Chan Medical Scool Worcester MA 01655 USA.
Robert MurphyHavey Institute for Global HealthNorthwestern University Chicago IL 60611 USA.ORCID https://orcid.org/0000-0003-3936-2052
Apurv SoniProgram in Digital Medicine, Department of MedicineUMass Chan Medical School Worcester MA 01655 USA.
Steven SchachterCenter for Integration of Medicine and Innovative Technology Boston MA 02114 USA.ORCID https://orcid.org/0000-0003-1849-8823

Funding

The Center for Advancing Point of Care in Heart, Lung, Blood and Sleep DiseasesU54HL143541 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BRYAN O BUCHHOLZ, Nathaniel Scott Hafer · 2018 to 2026
$141.0M
Technology Training and Dissemination CoreU54EB027690 · NIBIB · EMORY UNIVERSITY · PI Wilbur A Lam · 2018 to 2026
$96.1M
Rapid Fluorescence-Based Determination of Antibiotic SusceptibilityU54EB015408 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI PARRISH, JOHN A, SCHACHTER, STEVEN · 2012 to 2022
$49.2M
TrainingU54EB007958 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Matthew Hamill · 2007 to 2026
$34.6M
The Center for Innovation in Point-of-Care Technologies for HIV/AIDS atNorthwestern University (C-THAN) Supplemental RequestU54EB027049 · NIBIB · NORTHWESTERN UNIVERSITY · PI Kara M Palamountain · 2018 to 2026
$24.0M
NHLBI NIH HHS U54 HL143541NIBIB NIH HHS U54 EB007958NIBIB NIH HHS U54 EB015408NIBIB NIH HHS U54 EB027049NIBIB NIH HHS U54 EB027690
6 · The paper itself

Abstract

The National Institutes of Health's Rapid Acceleration of Diagnostics (RADx) program answered the call to accelerate the development of point-of-care (POC) and over-the-counter (OTC) COVID-19 tests. The widespread availability and access to self-tests has increased the public's familiarity and acceptance of at-home diagnostics. This paper examines the current state of OTC diagnostic testing, discusses potential applications of OTC testing, and highlights the implications of widespread OTC testing for clinical medicine.

Indexed as

Diagnosticsin vitro diagnosticsOTCpoint of careviral testing

Identifiers

PMID39906263
PMCPMC11793479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.