Evidence map›Paper›PMID 39906209›Full record

ReviewFrontiers in cellular and infection microbiology2024

Decoding mitochondrial DNA damage and repair associated with

Aashirwad Shahi, Dawit Kidane

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Mitochondrial Stress inAntioxidants (Basel, Switzerland) · 2026
    Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Aashirwad ShahiDepartment of Physiology and Biophysics, College of Medicine, Howard University, Washington, DC, United States.
Dawit KidaneDepartment of Physiology and Biophysics, College of Medicine, Howard University, Washington, DC, United States.

Funding

Linking defects in DNA polymerase beta to mitochondrial dysfunction and cytosolic nucleic acid sensor in Helicobacter pylori associated inflammationR01AI179899 · NIAID · HOWARD UNIVERSITY · PI Dawit Kidane Mulat · 2024 to 2026
$1.3M
The Role of Base Excision Repair in Regulating DNA-Mediated Inflammatory Signaling PathwaysR21CA249346 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI KIDANE MULAT, DAWIT · 2021 to 2021
$394k
NCI NIH HHS R21 CA249346NIAID NIH HHS R01 AI179899
6 · The paper itself

Abstract

Mitochondrial genomic stability is critical to prevent various human inflammatory diseases. Bacterial infection significantly increases oxidative stress, driving mitochondrial genomic instability and initiating inflammatory human disease. Oxidative DNA base damage is predominantly repaired by base excision repair (BER) in the nucleus (nBER) as well as in the mitochondria (mtBER). In this review, we summarize the molecular mechanisms of spontaneous and

Indexed as

DNA DamageDNA, MitochondrialDNA RepairHelicobacter InfectionsHelicobacter pyloriAnimalsDNA ReplicationGenomic InstabilityHumansImmunity, InnateMitochondriaOxidative StressDNA, Mitochondrialbase excision DNA repaircGAS-STINGcytosolic DNAgenomic instabilityH. pyloriinnate immune signalingmitochondrial DNA damage and repairType I interferon response

Identifiers

PMID39906209
PMCPMC11790445

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.