Successful Pregnancy in a Patient with Crohn's Disease and Short Bowel Syndrome: Off Total Parenteral Nutrition and On Teduglutide, a Glucagon-Like Peptide-2 Analog - A Case Report.

Maria M Dahar, MacKenzie Both, Linda M Lord, Carly Densmore, Lawrence J Saubermann

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Article in Case reports in gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Maria M DaharCarondelet St. Joseph's Hospital, Tucson, AZ, USA.

MacKenzie BothDivision of Gastroenterology, Hepatology and Endoscopy, University of Rochester Medical Center, Rochester, NY, USA.

Linda M LordDivision of Gastroenterology, Hepatology and Endoscopy, University of Rochester Medical Center, Rochester, NY, USA.

Carly DensmoreNutrition Support Clinic, University of Rochester Medical Center, Rochester, NY, USA.

Lawrence J SaubermannDivision of Gastroenterology, Hepatology and Endoscopy, University of Rochester Medical Center, Rochester, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Patients with short bowel syndrome (SBS) on conventional oral diets often face nutritional deficiencies and dehydration, a challenge further compounded during pregnancy. This case report describes the use of a glucagon-like peptide-2 (GLP-2) analog in the nutritional management of an SBS patient dependent on total parenteral nutrition (TPN). Case Presentation: A 29-year-old woman with a significant medical history of Crohn's disease leading to SBS was traditionally dependent on TPN for sustenance. During her pregnancy, she was successfully managed with a GLP-2 analog, which enabled her to wean off TPN. This successful management underscores the therapeutic potential of GLP-2 analogs in effectively altering the nutritional landscape for SBS patients, including during the physiologically demanding period of pregnancy. Conclusion: GLP-2 analogs helped with the nutritional management of patients with SBS during pregnancy and helped them wean off TPN. There is a need for further research and exploration into GLP-2 analogs as viable alternatives to conventional treatments such as TPN in the care and management of SBS patients during pregnancy.

Indexed as

Case reportCrohn’s diseaseGlucagon-like peptide-2 analogShort bowel syndrome

Identifiers

PMID39906192

DOI10.1159/000543291

PMCPMC11793910

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