Klinefelter syndrome diagnosed at autopsy and small-cell lung carcinoma.

Haruyasu Sakuranaka, Ryoma Tanaka, Yuji Yamakawa, Shiho Yamada, Komei Igei, Yasuo Asai

Abstract readCase Reports

In one paragraph

Article in Respiratory medicine case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Haruyasu SakuranakaRespiratory Medicine, Tokyo Metropolitan Toshima Hospital, 33-1, Sakaecho, Itabashi-Ku, Tokyo, 173-0015, Japan.

Ryoma TanakaRespiratory Medicine, Tokyo Metropolitan Toshima Hospital, 33-1, Sakaecho, Itabashi-Ku, Tokyo, 173-0015, Japan.

Yuji YamakawaRespiratory Medicine, Tokyo Metropolitan Toshima Hospital, 33-1, Sakaecho, Itabashi-Ku, Tokyo, 173-0015, Japan.

Shiho YamadaRespiratory Medicine, Tokyo Metropolitan Toshima Hospital, 33-1, Sakaecho, Itabashi-Ku, Tokyo, 173-0015, Japan.

Komei IgeiRespiratory Medicine, Tokyo Metropolitan Toshima Hospital, 33-1, Sakaecho, Itabashi-Ku, Tokyo, 173-0015, Japan.

Yasuo AsaiRespiratory Medicine, Tokyo Metropolitan Toshima Hospital, 33-1, Sakaecho, Itabashi-Ku, Tokyo, 173-0015, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Klinefelter syndrome is characterized by endocrine abnormalities, gynecomastia, female-like body shape, and mild intellectual disability. However, the diagnosis of Klinefelter syndrome is often missed due to the lack of characteristic findings. Computed tomography revealed a mass in the left lung of a 66-year-old man. He was diagnosed with small-cell lung carcinoma. Chemotherapy was administered, but the disease progressed, eventually leading to death. No significant changes were observed in the external genitalia or breast, but the autopsy showed testicular atrophy. XXY cells were seen in fluorescence in situ hybridization, and Klinefelter syndrome was diagnosed. Although chemotherapy causes testicular atrophy, Klinefelter syndrome should be considered in cases of severe testicular atrophy.

Indexed as

AutopsyFluorescence in situ hybridizationKlinefelter syndromeLung cancerSmall-cell lung carcinoma

Identifiers

PMID39906138

DOI10.1016/j.rmcr.2025.102166

PMCPMC11791344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.