ArticleInorganic chemistry2025
Dual-Action NO Delivery from One Mixed Metal Metal-Organic Framework.
Article in Inorganic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Harnessing gasotransmitters for orthopaedic infection therapy: Mechanisms and advanced delivery platforms.Bioactive materials · 2027Review
- Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Cu-based metal-organic frameworks: synthesis, biomedical applications, and beyond.Discover nano · 2026Review
- Bionic Microneedle Patch Inspired by Drosophila Tarsal Paws Boosts Healing in Bacterial Infectious Stomatitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Reversible Binding of Nitric Oxide in a Cu(II)-Containing Microporous Metal-Organic Framework.Molecules (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Owing to their varied and controllable reticular chemistry, metal-organic frameworks (MOFs) represent excellent, structurally precise material platforms for creating multifunctional devices. This flexibility allows the design of MOFs to feature two different delivery mechanisms for the medicinal gas nitric oxide (NO) within one structure: a rapid, kinetic release of preadsorbed NO and subsequent continuous, catalytic generation of NO on exposure to a suitable substrate. In our approach, this was realized by preparing mixed metal MOF-74 analogues (also known as CPO-27) combining two metals, namely, nickel and copper. The introduction of 10 atom % nickel into Cu-MOF-74 provides a material platform with a number of excellent properties: (i) a high capacity of NO can be released with a moisture-triggered mechanism; (ii) the available copper sites allow the (potentially indefinite) catalytic generation of NO in the presence of S-nitrosoglutathione (GSNO), a store of NO in the human body; and (iii) it features prolonged material stability on exposure to phosphates. This material therefore shows great promise as part of the next generation of multifunctional MOF-based medicinal devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.