Evidence map›Paper›PMID 39905948›Full record

ArticleFuture microbiology2025

Efficacy of nitrofuran derivatives against biofilms of

Carolina Orlando Vaso, Níura Madalena Bila, Rosângela Aparecida Moraes da Silva, Angélica Romão de Carvalho, Jennyfie Araújo Belizário, Fabiana Pandolfi, Daniela De Vita, Martina Bortolami, Maria José Soares Mendes-Giannini, Luigi Scipione and 4 more

Abstract read
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In one paragraph

Article in Future microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Carolina Orlando VasoDepartment of Clinical Analysis, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Araraquara, Brazil.ORCID 0000-0002-4629-680X
Níura Madalena BilaDepartment of Clinical Analysis, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Araraquara, Brazil.ORCID 0000-0002-4236-3366
Rosângela Aparecida Moraes da SilvaDepartment of Clinical Analysis, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Araraquara, Brazil.
Angélica Romão de CarvalhoDepartment of Clinical Analysis, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Araraquara, Brazil.
Jennyfie Araújo BelizárioDepartment of Clinical Analysis, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Araraquara, Brazil.
Fabiana PandolfiDepartment of Scienze di Base e Applicate per l'Ingegneria, Sapienza University of Rome, Rome, Italy.
Daniela De VitaDepartment of Environmental Biology, Sapienza University of Rome, Rome, Italy.
Martina BortolamiDepartment of Scienze di Base e Applicate per l'Ingegneria, Sapienza University of Rome, Rome, Italy.
Maria José Soares Mendes-GianniniDepartment of Clinical Analysis, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Araraquara, Brazil.
Luigi ScipioneDepartment of Chimica e Tecnologia del Farmaco, Sapienza University of Rome, Rome, Italy.
Roberto Di SantoDepartment of Chemistry and Technology of Drug, Instituto Pasteur, Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, Italy.
Roberta CostiDepartment of Chemistry and Technology of Drug, Instituto Pasteur, Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, Italy.
Caroline Barcelos Costa-OrlandiDepartment of Clinical Analysis, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Araraquara, Brazil.
Ana Marisa Fusco-AlmeidaDepartment of Clinical Analysis, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Araraquara, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the efficacy of two nitrofuran derivatives against biofilms formed by two strains of

methodsThe metabolic activity of biofilms was measured after treatment using the XTT reduction assay. Scanning electron microscopy (SEM) and confocal microscopy were used to observe damage to mature biofilms. Survival curves were generated for

resultsThe compounds showed efficacy against early and mature biofilms at concentrations equal to or up to two times higher than those required to eliminate planktonic fungal cells (3.90 to 31.25 μg/mL). Micrographs showed a reduction in metabolic activity, biofilm thickness, and extracellular matrix. In addition, the compounds showed little or no toxicity in alternative models, even at the highest concentrations tested.

conclusionThese results are promising for the development of new therapeutic alternatives, especially for species, such as

Indexed as

Antifungal AgentsBiofilmsHistoplasmaNitrofuransAnimalsCaenorhabditis elegansDisease Models, AnimalHistoplasmosisMicrobial Sensitivity TestsMicroscopy, Electron, ScanningMothsZebrafishAntifungal AgentsNitrofuransalternative animalsAntifungal activitybiofilmCaenorhabditis elegansGalleria mellonellanitrofuranstoxicityzebrafish

Identifiers

PMID39905948
PMCPMC11951717

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.