Evidence map›Paper›PMID 39905828›Full record

ArticleMolecular pain

Upregulation of the neuropeptide receptor calcitonin receptor-like in the spinal cord via MLL2 in a mouse model of paclitaxel-induced peripheral neuropathy.

Salvador Sierra, Sara M Herz, Doan On, Mikhail G Dozmorov, M Imad Damaj, Javier Gonzalez-Maeso

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Salvador SierraDepartment of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Sara M HerzDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Doan OnDepartment of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Mikhail G DozmorovDepartment of Biostatistics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
M Imad DamajDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Javier Gonzalez-MaesoDepartment of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.ORCID 0000-0003-3105-3204

Funding

Structure and function of the 5HT2A/mGluR2 complex in schizophreniaR01MH084894 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI Javier Gonzalez-Maeso · 2009 to 2026
$6.8M
NIMH NIH HHS R01 MH084894
6 · The paper itself

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and severe side effect affecting cancer patients undergoing paclitaxel treatment. Growing evidence underscores the pivotal role of calcitonin-related peptide (CGRP) in the development of CIPN. Repeated administration of paclitaxel induces alterations in CGRP release from sensory neurons within the dorsal root ganglia (DRG). The density of the CGRP receptor is most prominent in the dorsal horn of the spinal cord, where it overlaps with the distribution of CGRP. However, the impact of chemotherapy treatment on expression of the CGRP receptor in the spinal cord remains unclear, as well as the potential therapeutic benefits of a CGRP receptor antagonist in an animal model of CIPN. Using a mouse model of paclitaxel-induced mechanical hypersensitivity, we show upregulation of

Indexed as

Calcitonin Receptor-Like ProteinHistone-Lysine N-MethyltransferasePaclitaxelPeripheral Nervous System DiseasesSpinal CordUp-RegulationAnimalsCalcitonin Gene-Related PeptideDisease Models, AnimalGanglia, SpinalHyperalgesiaMaleMiceMice, Inbred C57BLRNA, MessengerCalcitonin Gene-Related PeptideCalcitonin Receptor-Like ProteinHistone-Lysine N-MethyltransferasePaclitaxelRNA, MessengerantinociceptionCGRP receptorChemotherapy-induced peripheral neuropathy (CIPN)pain

Identifiers

PMID39905828
PMCPMC11795615

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.