Evidence map›Paper›PMID 39905778›Full record

ReviewJournal of intensive care medicine2026

Muscle Dysfunction and Physical Recovery After Critical Illness.

Matthew F Mart, Joshua I Gordon, Felipe González-Seguel, Kirby P Mayer, Nathan Brummel

Abstract readReview
In one paragraph

Review in Journal of intensive care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Redefining success: Incorporating long-term survival outcomes into routine benchmarking.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025
    Article
  6. Early Neuromuscular Electrical Stimulation and In-Bed Leg Cycling Preserve Quadriceps Femoris Muscle Thickness in Critically Ill Patients.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2025
    Article
  7. Article
  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matthew F MartDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-6727-8838
Joshua I GordonDivision of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Felipe González-SeguelDepartment of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, USA.ORCID 0000-0001-9099-2389
Kirby P MayerDepartment of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, USA.ORCID 0000-0003-3844-3846
Nathan BrummelCritical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Nashville, TN, USA.ORCID 0000-0003-4308-0015

Funding

Institutional Career Development CoreKL2TR002245 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$9.3M
Muscle and physical function recovery after acute critical illnessR01AR081002 · NIAMS · UNIVERSITY OF KENTUCKY · PI Esther E Dupont-Versteegden · 2023 to 2026
$1.7M
Long Term Outcomes of Physical Activity in Older Adults with Critical IllnessK76AG054864 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BRUMMEL, NATHAN E · 2016 to 2020
$826k
Cellular and Physical Function Outcomes Leading to Failed Muscle Recovery After Critical IllnessK23AR079583 · NIAMS · UNIVERSITY OF KENTUCKY · PI Kirby P Mayer · 2022 to 2026
$744k
Surrogate Assessment of Frailty using Electronic Tools (SAFE-T)R03AG083556 · NIA · OHIO STATE UNIVERSITY · PI BRUMMEL, NATHAN E · 2024 to 2024
$158k
AHRQ HHS T32 HS029590NCATS NIH HHS KL2 TR002245NIAMS NIH HHS K23 AR079583NIAMS NIH HHS R01 AR081002NIA NIH HHS K76 AG054864NIA NIH HHS R03 AG083556NIMHD NIH HHS L32 MD017732RRD VA IK2 RX004799
6 · The paper itself

Abstract

During critical illness, patients experience significant and rapid onsets of muscle wasting and dysfunction with loss of strength, mass, and power. These deficits often persist long after the ICU, leading to impairments in physical function including reduced exercise capacity and increased frailty and disability. While there are numerous studies describing the epidemiology of impaired muscle and physical function in the ICU, there are significantly fewer data investigating mechanisms of prolonged and persistent impairments in ICU survivors. Additionally, while several potential clinical risk factors associated with poor physical recovery have been identified, there remains a dearth of interventions that have effectively improved outcomes long-term among survivors. In this article, we aim to provide a thorough, evidence-based review of the current state of knowledge regarding muscle dysfunction and physical function after critical illness with a focus on post-ICU and post-hospitalization phase of recovery.

Indexed as

Critical IllnessMuscular AtrophyRecovery of FunctionExercise ToleranceHumansIntensive Care UnitsMuscle StrengthRisk FactorsSurvivorscritical illnessICU-acquired weaknessmusclephysical functionpost intensive care syndrome

Identifiers

PMID39905778
PMCPMC12852493

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.