ArticleThe American journal of sports medicine2025
fMRI Activation in Sensorimotor Regions at 6 Weeks After Anterior Cruciate Ligament Reconstruction.
Article in The American journal of sports medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neural activity differences and their functional and clinical correlates after anterior cruciate ligament reconstruction: A systematic review of task-based fMRI studies.Experimental brain research · 2026Pooled it
- Eight weeks of visual perturbation training effects on unanticipated cutting lower-limb biomechanics and errors in male athletes following anterior cruciate ligament reconstruction: a randomized controlled clinical trial (RCT).BMC musculoskeletal disorders · 2026Trial
- Cross-education effects of healthy-side lower-limb strength training on neuromuscular function recovery following anterior cruciate ligament reconstruction: a randomized controlled trial.Journal of orthopaedic surgery and research · 2026Trial
- Distinct Movement-Related Cortical Control Following Anterior Cruciate Ligament Injury: A Scoping Review.Sports medicine - open · 2026Review
- Comparative efficacy and mechanistic insights of non-invasive neuromodulation and motor rehabilitation on functional reorganization of the supplementary motor area in subacute stroke: a narrative review.Frontiers in physiology · 2026Review
- Advances in Research on Brain Structure and Activation Characteristics in Patients with Anterior Cruciate Ligament Reconstruction: A Systematic Review.Brain sciences · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundBrain activity during knee movements is altered throughout the sensorimotor network after anterior cruciate ligament reconstruction (ACLR). Patients at 2 to 5 years after surgery appear to require greater neural activity to perform basic knee movement patterns, but it is unclear if brain activity differences within sensorimotor regions are present early after surgery. It is also unknown whether uninvolved knee movements elicit similar or unique activity compared with involved knee movements. PURPOSE: To examine brain activity in sensorimotor regions during involved and uninvolved knee movements in patients at 6 weeks after ACLR compared with control participants. STUDY
designCohort study; Level of evidence, 2.
methodsA total of 15 patients who underwent ACLR (mean age, 21.9 ± 4.3 years [range, 17-29 years]; 8 female) and 15 control participants performed 30-second blocks of repeated knee flexion and extension, followed by 30 seconds of rest, during functional magnetic resonance imaging. Regions of interest included the right and left primary motor cortex (M1), right and left primary somatosensory cortex (S1), supplementary motor area (SMA), precuneus, and lingual gyrus. Activity from task-relevant voxels (move > rest) was extracted, and generalized estimating equations evaluated the main effect of group and group-by-limb interaction. Effect sizes were calculated using the Cohen
resultsReduced brain activity during knee flexion and extension was observed in the ACLR group in the ipsilateral M1 and S1, contralateral S1, SMA, and precuneus during movements of the involved and uninvolved knees. There were no group-by-limb interaction effects, indicating no significant differences between the involved knee and uninvolved knee in the ACLR group. Medium to large effect sizes were identified for between-group differences in all regions.
conclusionAt 6 weeks after ACLR, patients exhibited bilateral reductions in brain activity during knee movements in multiple sensorimotor regions. These identified regions are associated with motor planning, motor execution, somatosensory function, and sensorimotor integration. These data indicate that ACLR affected sensorimotor brain activity in both limbs during the early postoperative phase of rehabilitation.
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